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PDE8B phosphodiesterase 8B [ Homo sapiens (human) ]

Gene ID: 8622, updated on 5-Mar-2024

Summary

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Official Symbol
PDE8Bprovided by HGNC
Official Full Name
phosphodiesterase 8Bprovided by HGNC
Primary source
HGNC:HGNC:8794
See related
Ensembl:ENSG00000113231 MIM:603390; AllianceGenome:HGNC:8794
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADSD; PPNAD3
Summary
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Expression
Biased expression in thyroid (RPKM 82.4), brain (RPKM 15.1) and 5 other tissues See more
Orthologs
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Genomic context

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See PDE8B in Genome Data Viewer
Location:
5q13.3
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (77086715..77428256)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (77568346..77910865)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76476129..76724081)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76326467-76327046 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76325887-76326466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16108 Neighboring gene angiogenic factor with G-patch and FHA domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76383973-76384573 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76382768-76383369 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76383370-76383972 Neighboring gene ZBED3 antisense RNA 1 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene uncharacterized LOC124901008 Neighboring gene zinc finger BED-type containing 3 Neighboring gene Sharpr-MPRA regulatory region 15273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76468397-76468898 Neighboring gene high mobility group box 1 pseudogene 35 Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76618089-76618784 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:76672412-76673040 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:76752518-76752693 Neighboring gene uncharacterized LOC124901009 Neighboring gene WD repeat domain 41 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76787603-76788526 Neighboring gene ribosomal protein S2 pseudogene 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clinical findings of autosomal-dominant striatal degeneration and PDE8B mutation screening in parkinsonism and related disorders. Ni J, et al. Parkinsonism Relat Disord, 2019 Dec. PMID 31726290
  2. PDE8B mutation is not associated with Parkinson's disease in a Taiwanese population. Fan TS, et al. Neurobiol Aging, 2018 Nov. PMID 29909144
  3. A novel mutation of PDE8B Gene in a Japanese family with autosomal-dominant striatal degeneration. Azuma R, et al. Mov Disord, 2015 Dec. PMID 26769607
  4. Genetic association study of phosphodiesterase 8B gene with subclinical hypothyroidism in pregnant women. Yang S, et al. Endocr Res, 2015. PMID 25822812
  5. Frequency and effect on serum TSH of phosphodiesterase 8B (PDE8B) gene polymorphisms in patients with sporadic nonautoimmune subclinical hypothyroidism. Agretti P, et al. J Endocrinol Invest, 2014 Feb. PMID 24497218

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.
    Title: cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.
  2. Clinical findings of autosomal-dominant striatal degeneration and PDE8B mutation screening in parkinsonism and related disorders.
    Title: Clinical findings of autosomal-dominant striatal degeneration and PDE8B mutation screening in parkinsonism and related disorders.
  3. Study shows that PDE8B may not play a major role in familial and early-onset Parkinson disease without distinctive lesions of the striatum on brain MRI in this Taiwanese population.
    Title: PDE8B mutation is not associated with Parkinson's disease in a Taiwanese population.
  4. Single-nucleotide polymorphism in PDE8B gene is associated with Hashimoto's thyroiditis.
    Title: Association of established hypothyroidism-associated genetic variants with Hashimoto's thyroiditis.
  5. replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation
    Title: Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS).
  6. a heterozygous nonsense mutation in the first exon of cyclic nucleotide phosphodiesterase 8B gene, which is predicted to disrupt all important functional domains of the cyclic nucleotide phosphodiesterase 8B protein, in two members of family with autosomal-dominant striatal degeneration
    Title: A novel mutation of PDE8B Gene in a Japanese family with autosomal-dominant striatal degeneration.
  7. Genetic variation of the PDE8B gene may be involved in the etiology of subclinical hypothyroidism in pregnant women.
    Title: Genetic association study of phosphodiesterase 8B gene with subclinical hypothyroidism in pregnant women.
  8. A prevalence of the minor allele of PDE8B gene polymorphism associated with elevated serum levels of TSH was demonstrated in patients affected by sporadic nonautoimmune subclinical hypothyroidism.
    Title: Frequency and effect on serum TSH of phosphodiesterase 8B (PDE8B) gene polymorphisms in patients with sporadic nonautoimmune subclinical hypothyroidism.
  9. rs4704397 is associated with thyroid function, risk of MI, and body height.
    Title: The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction, and body height: the Tromsø study.
  10. rs4704397 in phosphodiesterase 8B is associated with thyrotropin and thyroid hormone concentrations
    Title: Associations of rs4704397 in phosphodiesterase 8B with thyrotropin and thyroid hormone concentrations.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Autosomal dominant striatal neurodegeneration type 1
MedGen: C4310808 OMIM: 609161 GeneReviews: Not available
Compare labs
Pigmented nodular adrenocortical disease, primary, 3
MedGen: C3280094 OMIM: 614190 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
EBI GWAS Catalog
Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search.
EBI GWAS Catalog
Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
EBI GWAS Catalog
Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function.
EBI GWAS Catalog
Novel associations for hypothyroidism include known autoimmune risk loci.
EBI GWAS Catalog
Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in behavioral fear response IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of steroid hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
  
involved_in operant conditioning IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Names
3',5' cyclic nucleotide phosphodiesterase 8B
cell proliferation-inducing gene 22 protein
NP_001025022.1
NP_001025023.1
NP_001025024.1
NP_001025025.1
NP_001336677.1
NP_001336678.1
NP_001336679.1
NP_001336680.1
NP_001336681.1
NP_001336682.1
NP_001362991.1
NP_001362992.1
NP_001362993.1
NP_001362994.1
NP_001362995.1
NP_001362996.1
NP_001362997.1
NP_001362998.1
NP_001362999.1
NP_001363000.1
NP_001363001.1
NP_001363002.1
NP_001363003.1
NP_001363004.1
NP_001401551.1
NP_001401552.1
NP_003710.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023364.2 RefSeqGene

    Range
    35429..253005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029851.4 → NP_001025022.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 3

    See identical proteins and their annotated locations for NP_001025022.1

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS34192.1
    UniProtKB/Swiss-Prot
    O95263
    UniProtKB/TrEMBL
    B3KN77
    Related
    ENSP00000330428.3, ENST00000346042.7
    Conserved Domains (3) summary
    PHA02597
    Location:158 → 311
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:517 → 764
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase

  2. NM_001029852.4 → NP_001025023.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 5

    See identical proteins and their annotated locations for NP_001025023.1

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KF457931
    Consensus CDS
    CCDS34190.1
    UniProtKB/Swiss-Prot
    O95263
    UniProtKB/TrEMBL
    B3KN77
    Related
    ENSP00000331336.4, ENST00000333194.8
    Conserved Domains (4) summary
    cd00130
    Location:284 → 376
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:559 → 806
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:279 → 377
    PAS_9; PAS domain

  3. NM_001029853.4 → NP_001025024.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 4

    See identical proteins and their annotated locations for NP_001025024.1

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS34193.1
    UniProtKB/Swiss-Prot
    O95263
    UniProtKB/TrEMBL
    B3KN77
    Related
    ENSP00000345646.4, ENST00000342343.8
    Conserved Domains (4) summary
    cd00130
    Location:264 → 356
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:594 → 841
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:259 → 357
    PAS_9; PAS domain

  4. NM_001029854.4 → NP_001025025.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 2

    See identical proteins and their annotated locations for NP_001025025.1

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS34191.1
    UniProtKB/Swiss-Prot
    O95263
    UniProtKB/TrEMBL
    B3KN77
    Related
    ENSP00000345446.3, ENST00000340978.7
    Conserved Domains (2) summary
    pfam00233
    Location:567 → 814
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase

  5. NM_001349748.3 → NP_001336677.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:613 → 860
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:279 → 376
    PAS_9; PAS domain

  6. NM_001349749.3 → NP_001336678.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:635 → 882
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:301 → 398
    PAS_9; PAS domain

  7. NM_001349750.3 → NP_001336679.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (2) summary
    pfam00233
    Location:534 → 781
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:200 → 297
    PAS_9; PAS domain

  8. NM_001349751.3 → NP_001336680.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:613 → 805
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:279 → 376
    PAS_9; PAS domain

  9. NM_001349752.3 → NP_001336681.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    COG2202
    Location:46 → 273
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:512 → 759
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:178 → 275
    PAS_9; PAS domain

  10. NM_001349753.2 → NP_001336682.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS87307.1
    UniProtKB/TrEMBL
    A0A2R8Y4E6
    Conserved Domains (3) summary
    COG2202
    Location:24 → 251
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

  11. NM_001376062.1 → NP_001362991.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    COG2202
    Location:47 → 274
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:513 → 760
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:179 → 276
    PAS_9; PAS domain

  12. NM_001376063.1 → NP_001362992.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (4) summary
    COG2202
    Location:148 → 368
    PAS; PAS domain [Signal transduction mechanisms]
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:611 → 858
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:280 → 374
    PAS_9; PAS domain

  13. NM_001376064.1 → NP_001362993.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (4) summary
    COG2202
    Location:148 → 317
    PAS; PAS domain [Signal transduction mechanisms]
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:564 → 811
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:280 → 333
    PAS_9; PAS domain

  14. NM_001376065.1 → NP_001362994.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    PHA02597
    Location:157 → 310
    30.2; hypothetical protein; Provisional
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:516 → 763
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  15. NM_001376066.1 → NP_001362995.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    COG2202
    Location:27 → 254
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:493 → 740
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:159 → 256
    PAS_9; PAS domain

  16. NM_001376067.1 → NP_001362996.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS87307.1
    UniProtKB/TrEMBL
    A0A2R8Y4E6
    Conserved Domains (3) summary
    COG2202
    Location:24 → 251
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

  17. NM_001376068.1 → NP_001362997.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS87307.1
    UniProtKB/TrEMBL
    A0A2R8Y4E6
    Conserved Domains (3) summary
    COG2202
    Location:24 → 251
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:156 → 253
    PAS_9; PAS domain

  18. NM_001376069.1 → NP_001362998.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (1) summary
    pfam00233
    Location:486 → 733
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  19. NM_001376070.1 → NP_001362999.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (1) summary
    pfam00233
    Location:466 → 713
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  20. NM_001376071.1 → NP_001363000.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (1) summary
    pfam00233
    Location:465 → 712
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  21. NM_001376072.1 → NP_001363001.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (3) summary
    COG2202
    Location:47 → 274
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:513 → 705
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:179 → 276
    PAS_9; PAS domain

  22. NM_001376073.1 → NP_001363002.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (2) summary
    PHA02597
    Location:57 → 210
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:416 → 663
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  23. NM_001376074.1 → NP_001363003.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    Conserved Domains (2) summary
    PHA02597
    Location:37 → 190
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:396 → 643
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  24. NM_001376075.1 → NP_001363004.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Conserved Domains (2) summary
    PHA02597
    Location:34 → 187
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:393 → 640
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  25. NM_001414622.1 → NP_001401551.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    UniProtKB/TrEMBL
    A0A2R8Y4E6

  26. NM_001414623.1 → NP_001401552.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC008581, AC010234, AC022422, KC877015, KF457931
    UniProtKB/TrEMBL
    A0A2R8Y4E6

  27. NM_003719.5 → NP_003710.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1

    See identical proteins and their annotated locations for NP_003710.1

    Status: REVIEWED

    Source sequence(s)
    AC010234, AC022414, AC022422, KC877015, KF457931
    Consensus CDS
    CCDS4037.1
    UniProtKB/Swiss-Prot
    O95263, Q5J7V7, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2
    Related
    ENSP00000264917.6, ENST00000264917.10
    Conserved Domains (4) summary
    cd00130
    Location:284 → 376
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:614 → 861
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:279 → 377
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    77086715..77428256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    77568346..77910865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95263.2 GenPept UniProtKB/Swiss-Prot:O95263

Gene LinkOut

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