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cmk cytidylate kinase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885157, updated on 6-Oct-2023

Summary

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Gene symbol
cmk
Gene description
cytidylate kinase
Locus tag
Rv1712
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1939599..1940291)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene initiation inhibitor protein Neighboring gene segregation and condensation protein ScpA Neighboring gene segregation and condensation protein ScpB Neighboring gene RNA pseudouridine synthase Neighboring gene GTPase Der Neighboring gene oxidoreductase Neighboring gene 3-hydroxybutyryl-CoA dehydrogenase FadB Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase. Jaskulski L, et al. Arch Biochem Biophys, 2013 Aug 1. PMID 23756762
  2. Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv. Caceres RA, et al. J Mol Model, 2008 May. PMID 18343960
  3. The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP. Thum C, et al. J Bacteriol, 2009 Apr. PMID 19181797, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The thermodynamic signatures of cytidine 5'-monophosphate and 2'-deoxy-cytidine 5'-monophosphate binding to cmk showed favorable enthalpy and unfavorable entropy, and ATP binding was characterized by favorable changes in enthalpy and entropy.
    Title: Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase.
  2. Steady-state kinetics confirmed that M. tuberculosis CMK is a monomer that preferentially phosphorylates CMP and dCMP by a sequential mechanism.
    Title: The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP.
  3. molecular modeling & dynamics study of cytidylate kinase; model allowed identification of structural features responsible for ligand affinities; molecular dynamics simulations indicates the structural features responsible for stability of the structure
    Title: Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
cytidylate kinase
NP_216228.1
  • Cmk (CMP kinase) (cytidine monophosphate kinase) (ck). Belongs to the cytidylate kinase family,subfamily 1.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1939599..1940291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216228.1 cytidylate kinase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216228.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W7B5
    Conserved Domains (1) summary
    PRK00023
    Location:8 → 228
    cmk; (d)CMP kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPA9.1

Gene LinkOut

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Molecular Biology Databases