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fbpB diacylglycerol acyltransferase/mycolyltransferase Ag85B [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885785, updated on 6-Oct-2023

Summary

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Gene symbol
fbpB
Gene description
diacylglycerol acyltransferase/mycolyltransferase Ag85B
Locus tag
Rv1886c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
85B; mpt59
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Genomic context

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Sequence:
NC_000962.3 (2134890..2135867, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene resuscitation-promoting factor RpfC Neighboring gene chorismate mutase Neighboring gene hypothetical protein Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Computational Identification and Characterization of a Promiscuous T-Cell Epitope on the Extracellular Protein 85B of Mycobacterium spp. for Peptide-Based Subunit Vaccine Design. Hossain MS, et al. Biomed Res Int, 2017. PMID 28401156, Free PMC Article
  2. [Prokaryotic expression and immunological characteristics of Mycobacterium tuberculosis Rv1886c]. Tao C, et al. Wei Sheng Wu Xue Bao, 2014 Mar 4. PMID 24984525
  3. Recombinant Bacillus subtilis spores for the delivery of Mycobacterium tuberculosis Ag85B-CFP10 secretory antigens. Das K, et al. Tuberculosis (Edinb), 2016 Dec. PMID 27727129
  4. DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection. Dalmia N, et al. PLoS One, 2015. PMID 26317509, Free PMC Article
  5. Prime-boost bacillus Calmette-Guérin vaccination with lentivirus-vectored and DNA-based vaccines expressing antigens Ag85B and Rv3425 improves protective efficacy against Mycobacterium tuberculosis in mice. Xu Y, et al. Immunology, 2014 Oct. PMID 24773322, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recombinant Bacillus subtilis spores can be used for the delivery of Mycobacterium tuberculosis Ag85B-CFP10 secretory antigens.
    Title: Recombinant Bacillus subtilis spores for the delivery of Mycobacterium tuberculosis Ag85B-CFP10 secretory antigens.
  2. We found that the extracellular protein 85B displayed the most robust antigenicity among the proteins identified.ur results indicate that the identified peptide might be a universal candidate to produce an efficient epitope-based vaccine for Tuberculosis
    Title: Computational Identification and Characterization of a Promiscuous T-Cell Epitope on the Extracellular Protein 85B of Mycobacterium spp. for Peptide-Based Subunit Vaccine Design.
  3. These results indicate that the mycobacterial antigen 85 complex is a target for ficolins and mannose-binding lectin.
    Title: Mycobacterial antigen 85 complex (Ag85) as a target for ficolins and mannose-binding lectin.
  4. DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection.
    Title: DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection.
  5. Data indicate that enzymes antigen 85A, 85B and 85C have unique substrate preferences and are regulated by a second carbohydrate-binding site.
    Title: The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions.
  6. Suggest that the use of lentiviral or DNA vaccines containing the antigens Ag85B and Rv3425 to boost BCG is a good choice for the rational design of an efficient vaccination strategy against TB.
    Title: Prime-boost bacillus Calmette-Guérin vaccination with lentivirus-vectored and DNA-based vaccines expressing antigens Ag85B and Rv3425 improves protective efficacy against Mycobacterium tuberculosis in mice.
  7. Data indicate by using immunoinformatics tools to predict epitopes within the protein Ag85B.
    Title: In silico predicted mycobacterial epitope elicits in vitro T-cell responses.
  8. Ag85B effectively induce strongly Th1-tendency immune response and humoral response in mice.
    Title: [Prokaryotic expression and immunological characteristics of Mycobacterium tuberculosis Rv1886c].
  9. Sequenced the esxA, esxH, and fbpB genes of M. tuberculosis encoding ESAT-6, TB10.4, and Ag85B proteins, respectively, in a sample of 88 clinical isolates.
    Title: Assessment of the genetic diversity of Mycobacterium tuberculosis esxA, esxH, and fbpB genes among clinical isolates and its implication for the future immunization by new tuberculosis subunit vaccines Ag85B-ESAT-6 and Ag85B-TB10.4.
  10. Mycobacterium tuberculosis origin of replication and the promoter for immunodominant secreted antigen 85B are the targets of MtrA, the essential response regulator.
    Title: Mycobacterium tuberculosis origin of replication and the promoter for immunodominant secreted antigen 85B are the targets of MtrA, the essential response regulator.
Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Homology

General protein information

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Preferred Names
diacylglycerol acyltransferase/mycolyltransferase Ag85B
NP_216402.1
  • FbpB Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen); binds fibronectin facilitating attachment to host cells; also involved in maintaining cell wall integrity through the transfer of mycolyic acids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2134890..2135867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216402.1 diacylglycerol acyltransferase/mycolyltransferase Ag85B [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216402.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q847N4
    Conserved Domains (1) summary
    COG0627
    Location:3 → 324
    FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WQP1.1

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