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embC arabinosyltransferase C [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886112, updated on 6-Oct-2023

Summary

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Gene symbol
embC
Gene description
arabinosyltransferase C
Locus tag
Rv3793
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (4239863..4243147)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene decaprenylphosphoryl-beta-D-ribose oxidase Neighboring gene decaprenylphosphoryl-D-2-keto erythropentose reductase Neighboring gene arabinofuranosyltransferase Neighboring gene arabinosyltransferase A Neighboring gene arabinosyltransferase B Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan. Korkegian A, et al. J Biol Chem, 2014 Dec 19. PMID 25352598, Free PMC Article
  2. The critical role of embC in Mycobacterium tuberculosis. Goude R, et al. J Bacteriol, 2008 Jun. PMID 18424526, Free PMC Article
  3. Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. Sharma K, et al. J Bacteriol, 2006 Apr. PMID 16585755, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that loss of asparagine Asn-638 in arabinosyltransferase EmbC resulted in the synthesis of truncated lipoarabinomannan (LAM).
    Title: Mutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan.
  2. Results have identified embC as the key genes involved in LAM biosynthesis in M. tuberculosis and confirmed its essential role in this species.
    Title: The critical role of embC in Mycobacterium tuberculosis.
  3. increased transcription of embC, catalyzing arabinosylation of lipomannan (LM) to lipoarabinomannan (LAM), results in a high LAM/LM ratio, which in turn is a crucial factor in mycobacterial virulence.
    Title: Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo.
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General gene information

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Homology

General protein information

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Preferred Names
arabinosyltransferase C
NP_218310.1
  • EmbC (arabinosylindolylacetylinositol synthase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4239863..4243147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218310.1 arabinosyltransferase C [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218310.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024CBH6, A0A0B5HBJ2, A0A0B5HFG2, A0A0B5HP58, A0A0B5HSY1, A0A0G3VTF1
    Conserved Domains (3) summary
    pfam04602
    Location:225 → 681
    Arabinose_trans; Mycobacterial cell wall arabinan synthesis protein
    pfam14896
    Location:721 → 1092
    Arabino_trans_C; EmbC C-terminal domain
    pfam17689
    Location:53 → 221
    Arabino_trans_N; Arabinosyltransferase concanavalin like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WNL5.1

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