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fbpA diacylglycerol acyltransferase/mycolyltransferase Ag85A [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886132, updated on 6-Oct-2023

Summary

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Gene symbol
fbpA
Gene description
diacylglycerol acyltransferase/mycolyltransferase Ag85A
Locus tag
Rv3804c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
85A; mpt44
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Genomic context

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Sequence:
NC_000962.3 (4265642..4266658, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene membrane protein Neighboring gene MPT51/MPB51 antigen Neighboring gene terminal beta-(1->2)-arabinofuranosyltransferase Neighboring gene decaprenyl-phosphate phosphoribosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rapid loss of early antigen-presenting activity of lymph node dendritic cells against Ag85A protein following Mycobacterium bovis BCG infection. Xu Z, et al. BMC Immunol, 2018 Jun 25. PMID 29940854, Free PMC Article
  2. [Expression and immunogenicity of Ag85A protein of Mycobacterium tuberculosis]. Xu Z, et al. Wei Sheng Wu Xue Bao, 2016 May 4. PMID 29727142
  3. Using a prime and pull approach, lentivector vaccines expressing Ag85A induce immunogenicity but fail to induce protection against Mycobacterium bovis bacillus Calmette-Guérin challenge in mice. Britton G, et al. Immunology, 2015 Oct. PMID 26095282, Free PMC Article
  4. A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. Touchette MH, et al. ACS Infect Dis, 2017 May 12. PMID 28276676, Free PMC Article
  5. The Mycobacterium tuberculosis Ag85A is a novel diacylglycerol acyltransferase involved in lipid body formation. Elamin AA, et al. Mol Microbiol, 2011 Sep. PMID 21819455

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results showed that the early BCG Ag85A (Ag)-presenting activity of murine dendritic cells (DCs) was transient, appearing at 4 h and being barely detectable at 72 h.
    Title: Rapid loss of early antigen-presenting activity of lymph node dendritic cells against Ag85A protein following Mycobacterium bovis BCG infection.
  2. Ag85A protein can induce strong specific humoral and Th1 type cellular immune responses.
    Title: [Expression and immunogenicity of Ag85A protein of Mycobacterium tuberculosis].
  3. A screen for protein-protein interactions reveals a functional link between the virulence-associated lipid transporter LprG and the mycolyltransferase antigen 85A.
    Title: A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A.
  4. These results indicate that the mycobacterial antigen 85 complex is a target for ficolins and mannose-binding lectin.
    Title: Mycobacterial antigen 85 complex (Ag85) as a target for ficolins and mannose-binding lectin.
  5. Using a prime and pull approach, lentivector vaccines expressing Ag85A induce immunogenicity but fail to induce protection against Mycobacterium bovis bacillus Calmette-Guerin challenge in mice.
    Title: Using a prime and pull approach, lentivector vaccines expressing Ag85A induce immunogenicity but fail to induce protection against Mycobacterium bovis bacillus Calmette-Guérin challenge in mice.
  6. Data indicate that enzymes antigen 85A, 85B and 85C have unique substrate preferences and are regulated by a second carbohydrate-binding site.
    Title: The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions.
  7. The authors show that the enzyme possesses acyl-CoA:diacylglycerol acyltransferase (DGAT) activity in addition to its well-known function as mycolyltransferase.
    Title: The Mycobacterium tuberculosis Ag85A is a novel diacylglycerol acyltransferase involved in lipid body formation.
  8. findings revealed 6 proteins with high-affinity for the fbpA promoter, and 7 with specificity the fbpC promoter
    Title: Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis.
  9. analysis of enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms
    Title: Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms.
  10. In addition to immune recognition of Ag85A whole protein, peptide-mapping studies identified four immunogenic Ag85A peptides, which induced Th-1 immune responses in individual sarcoidosis subjects, suggesting a role in sarcoidosis immunopathogenesis.
    Title: Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosis.
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General gene information

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Homology

General protein information

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Preferred Names
diacylglycerol acyltransferase/mycolyltransferase Ag85A
NP_218321.1
  • secreted antigen 85-a FbpA; mycolyl transferase 85A (fibronectin-binding protein A) (antigen 85 complex A)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4265642..4266658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218321.1 diacylglycerol acyltransferase/mycolyltransferase Ag85A [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218321.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q847N5
    Conserved Domains (1) summary
    COG0627
    Location:5 → 329
    FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WQP3.1

Gene LinkOut

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