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glfT2 galactofuranosyl transferase GlfT [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886136, updated on 6-Oct-2023

Summary

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Gene symbol
glfT2
Gene description
galactofuranosyl transferase GlfT
Locus tag
Rv3808c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (4270366..4272279, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene decaprenyl-phosphate phosphoribosyltransferase Neighboring gene decaprenylphosphoryl-5-phosphoribose phosphatase Neighboring gene UDP-galactopyranose mutase Neighboring gene cell surface protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial Arabinogalactan. Wheatley RW, et al. J Biol Chem, 2012 Aug 10. PMID 22707726, Free PMC Article
  2. Expression, purification, and characterization of a galactofuranosyltransferase involved in Mycobacterium tuberculosis arabinogalactan biosynthesis. Rose NL, et al. J Am Chem Soc, 2006 May 24. PMID 16704275
  3. Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis. Alderwick LJ, et al. Protein Expr Purif, 2008 Apr. PMID 18248822
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial Arabinogalactan.
    Title: Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial Arabinogalactan.
  2. this purified enzyme transfers [14C]Galf to a range of both beta(1-->5) and beta(1-->6) linked digalactofuranosyl neoglycolipid acceptors with a distinct preference for the latter.
    Title: Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.
  3. recombinant enzyme, like the wild-type protein, is bifunctional and can synthesize both beta-(1-->6) and beta-(1-->5)-linkages in an alternating fashion.
    Title: Expression, purification, and characterization of a galactofuranosyltransferase involved in Mycobacterium tuberculosis arabinogalactan biosynthesis.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
galactofuranosyl transferase GlfT

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4270366..4272279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218325.1 galactofuranosyl transferase GlfT [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218325.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3LKF7
    Conserved Domains (2) summary
    COG1216
    Location:158 → 487
    GT2; Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism]
    pfam17994
    Location:9 → 152
    Glft2_N; Galactofuranosyltransferase 2 N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O53585.1

Gene LinkOut

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