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papA2 trehalose-2-sulfate acyltransferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886140, updated on 6-Oct-2023

Summary

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Gene symbol
papA2
Gene description
trehalose-2-sulfate acyltransferase
Locus tag
Rv3820c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (4284419..4285825, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene phosphotransferase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene integral membrane protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Kumar P, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17592143, Free PMC Article
  2. Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis. Bhatt K, et al. Microbiology (Reading), 2007 Feb. PMID 17259623
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PapA2 is responsible for the sequential acylation of trehalose-2-sulfate to form sulfolipid (1278) and is essential for SL-1 biosynthesis.
    Title: PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
  2. required for all acylation steps of Sulfolipid-I assembly.
    Title: Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
trehalose-2-sulfate acyltransferase
YP_178020.1
  • polyketide synthase associated protein PapA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4284419..4285825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_178020.1 trehalose-2-sulfate acyltransferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_178020.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A109SBJ0
    Conserved Domains (1) summary
    cl23853
    Location:71 → 336
    Condensation; Condensation domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIK7.1

Gene LinkOut

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Molecular Biology Databases