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pcaA cyclopropane mycolic acid synthase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886284, updated on 6-Oct-2023

Summary

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Gene symbol
pcaA
Gene description
cyclopropane mycolic acid synthase
Locus tag
Rv0470c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
umaA2
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Genomic context

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Sequence:
NC_000962.3 (560848..561711, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 3-hydroxybutyryl-CoA dehydrogenase Neighboring gene mycolic acid synthase UmaA Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene HTH-type transcriptional regulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block. Corrales RM, et al. J Biol Chem, 2012 Jul 27. PMID 22621931, Free PMC Article
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mycolic acid cyclopropane synthase PcaA, but not MmaA2, was phosphorylated by mycobacterial Ser/Thr kinases at Thr-168 and Thr-183
    Title: Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block.
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General gene information

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Homology

General protein information

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Preferred Names
cyclopropane mycolic acid synthase
YP_177730.1
  • mycolic acid synthase PcaA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    560848..561711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177730.1 cyclopropane mycolic acid synthase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177730.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3L669
    Conserved Domains (1) summary
    pfam02353
    Location:4 → 283
    CMAS; Mycolic acid cyclopropane synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPB3.1

Gene LinkOut

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Molecular Biology Databases