U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pckA phosphoenolpyruvate carboxykinase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886744, updated on 6-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
pckA
Gene description
phosphoenolpyruvate carboxykinase
Locus tag
Rv0211
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
pck1; pckG
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000962.3 (251782..253602)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene tRNA (guanine-N(7)-)-methyltransferase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene transcriptional regulator NadR Neighboring gene methyltransferase Neighboring gene fatty-acid--CoA ligase FadD4

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis. Machová I, et al. PLoS One, 2017. PMID 28135343, Free PMC Article
  2. The phosphoenolpyruvate carboxykinase of Mycobacterium tuberculosis induces strong cell-mediated immune responses in mice. Liu K, et al. Mol Cell Biochem, 2006 Aug. PMID 16691317
  3. Mycobacterium tuberculosis phosphoenolpyruvate carboxykinase is regulated by redox mechanisms and interaction with thioredoxin. Machová I, et al. J Biol Chem, 2014 May 9. PMID 24659783, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the regulatory role of C391 and C397 that form the S-S bridge and in the reduced form stabilize Pck tertiary structure and conformation for gluconeogenic and anaplerotic reactions, is reported.
    Title: The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis.
  2. The interaction between Pck and the reduced form of mycobacterial thioredoxin, gene expression of which is increased under hypoxic conditions, also increased the Pck anaplerotic activity.
    Title: Mycobacterium tuberculosis phosphoenolpyruvate carboxykinase is regulated by redox mechanisms and interaction with thioredoxin.
  3. The results indicate that PEPCK can effectively induce cell-mediated immune response by increasing activity of cytokines
    Title: The phosphoenolpyruvate carboxykinase of Mycobacterium tuberculosis induces strong cell-mediated immune responses in mice.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
phosphoenolpyruvate carboxykinase
NP_214725.1
  • iron-regulated, alternate gene names: pckG and pck1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    251782..253602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214725.1 phosphoenolpyruvate carboxykinase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214725.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4LRH6
    Conserved Domains (1) summary
    PRK04210
    Location:7 → 606
    PRK04210; phosphoenolpyruvate carboxykinase (GTP)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIH3.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous