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cysM O-phosphoserine sulfhydrylase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886867, updated on 6-Oct-2023

Summary

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Gene symbol
cysM
Gene description
O-phosphoserine sulfhydrylase
Locus tag
Rv1336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1503394..1504365)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene [CysO]-cysteine peptidase Neighboring gene sulfur carrier protein CysO Neighboring gene integral membrane protein Neighboring gene glutamate racemase Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C-terminal of CysM from Mycobacterium tuberculosis protects the aminoacrylate intermediate and is involved in sulfur donor selectivity. Agren D, et al. FEBS Lett, 2009 Jan 22. PMID 19101553
  2. O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis. O'Leary SE, et al. Biochemistry, 2008 Nov 4. PMID 18842002, Free PMC Article
  3. Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria. Agren D, et al. J Biol Chem, 2008 Nov 14. PMID 18799456
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results highlight features of CysM that might be of particular importance for cysteine biosynthesis under oxidative stress in M. tuberculosis.
    Title: The C-terminal of CysM from Mycobacterium tuberculosis protects the aminoacrylate intermediate and is involved in sulfur donor selectivity.
  2. cysteine synthase CysM is, in contrast to previous annotations, an O-phosphoserine-specific cysteine synthase
    Title: Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria.
  3. specificity of CysM for its amino acid substrate is more than 500-fold greater for O-phospho-L-serine than for O-acetyl-L-serine, suggesting that O-phospho-L-serine is the likely substrate in vivo
    Title: O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis.
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General gene information

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Homology

General protein information

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Preferred Names
O-phosphoserine sulfhydrylase
NP_215852.1
  • cysteine synthase B, (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1503394..1504365
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215852.1 O-phosphoserine sulfhydrylase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215852.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W692
    Conserved Domains (1) summary
    cl00342
    Location:7 → 306
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WP53.1

Gene LinkOut

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