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fbpC diacylglycerol acyltransferase/mycolyltransferase Ag85C [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886885, updated on 6-Oct-2023

Summary

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Gene symbol
fbpC
Gene description
diacylglycerol acyltransferase/mycolyltransferase Ag85C
Locus tag
Rv0129c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
85C; fbpC2; mpt45
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Genomic context

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Sequence:
NC_000962.3 (156578..157600, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene maltokinase Neighboring gene transmembrane protein Neighboring gene 3-hydroxyl-thioester dehydratase Neighboring gene acyl-CoA dehydrogenase FadE1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inactivation of the Mycobacterium tuberculosis antigen 85 complex by covalent, allosteric inhibitors. Favrot L, et al. J Biol Chem, 2014 Sep 5. PMID 25028518, Free PMC Article
  2. Antigen 85 variation across lineages of Mycobacterium tuberculosis-implications for vaccine and biomarker success. Kruh-Garcia NA, et al. J Proteomics, 2014 Jan 31. PMID 23891556
  3. Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis. Romero IC, et al. Tuberculosis (Edinb), 2010 Jan. PMID 19959397
  4. The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions. Backus KM, et al. J Biol Chem, 2014 Sep 5. PMID 25028517, Free PMC Article
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that chemical modification or mutation at cysteine residue leads to the disruption of the active site hydrogen-bonded network essential for antigen Ag85C catalysis.
    Title: Inactivation of the Mycobacterium tuberculosis antigen 85 complex by covalent, allosteric inhibitors.
  2. Data indicate that enzymes antigen 85A, 85B and 85C have unique substrate preferences and are regulated by a second carbohydrate-binding site.
    Title: The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions.
  3. data demonstrates that the greatest variation in Antigen 85 is ascribed to protein quantities, whereas few transcriptional differences were found. In addition, the ratio of Antigen 85 A, to B, to C is conserved within clades and phylogenetic neighbors.
    Title: Antigen 85 variation across lineages of Mycobacterium tuberculosis-implications for vaccine and biomarker success.
  4. findings revealed 6 proteins with high-affinity for the fbpA promoter, and 7 with specificity the fbpC promoter
    Title: Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis.
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General gene information

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Homology

General protein information

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Preferred Names
diacylglycerol acyltransferase/mycolyltransferase Ag85C
YP_177694.1
  • fibronectin-binding protein C, secreted antigen 85c,mycolyl transferase 85C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    156578..157600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177694.1 diacylglycerol acyltransferase/mycolyltransferase Ag85C [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177694.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    D6MJP8
    Conserved Domains (1) summary
    COG0627
    Location:8 → 328
    FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WQN9.1

Gene LinkOut

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Molecular Biology Databases
Research Materials