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Rv1264 adenylyl cyclase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887035, updated on 4-Feb-2024

Summary

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Gene symbol
Rv1264
Gene description
adenylyl cyclase
Locus tag
Rv1264
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1411894..1413087)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene amidase AmiB Neighboring gene ncRNA Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264. Dittrich D, et al. Int J Med Microbiol, 2006 Dec. PMID 17005450
  2. The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme. Tews I, et al. Science, 2005 May 13. PMID 15890882
  3. The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid. Findeisen F, et al. J Mol Biol, 2007 Jun 22. PMID 17482646
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings show that adenylyl cyclase Rv1264 is rendered a pH sensor by its N-terminal domain
    Title: The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme.
  2. in-depth structural and functional analysis of the regulatory domain of Rv1264.
    Title: The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid.
  3. A Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264 is charcterised.
    Title: Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
adenylyl cyclase
NP_215780.1
  • ATP pyrophosphate-lyase (adenylate cyclase)The N terminus seems to be a potential novel regulator of adenylyl cyclase activity (autoinhibitory domain). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1411894..1413087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215780.1 adenylyl cyclase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215780.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3L7X4
    Conserved Domains (2) summary
    cd07556
    Location:215 → 334
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
    pfam16701
    Location:9 → 193
    Ad_Cy_reg; Adenylate cyclase regulatory domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMU9.1

Gene LinkOut

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Molecular Biology Databases
Research Materials