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Rv1248c multifunctional 2-oxoglutarate dehydrogenase E1 component /2-oxoglutarate dehydrogenase dihydrolipoyllysine-residue succinyltransferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887084, updated on 6-Oct-2023

Summary

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Gene symbol
Rv1248c
Gene description
multifunctional 2-oxoglutarate dehydrogenase E1 component /2-oxoglutarate dehydrogenase dihydrolipoyllysine-residue succinyltransferase
Locus tag
Rv1248c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1389357..1393052, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene short-chain type dehydrogenase/reductase Neighboring gene toxin RelE Neighboring gene antitoxin RelB Neighboring gene membrane protein Neighboring gene MFS-type drug transporter Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase. Maksymiuk C, et al. Tuberculosis (Edinb), 2015 Dec. PMID 26547230, Free PMC Article
  2. Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. de Carvalho LP, et al. Chem Biol, 2010 Apr 23. PMID 20416504, Free PMC Article
  3. Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase. Balakrishnan A, et al. J Biol Chem, 2013 Jul 26. PMID 23760263, Free PMC Article
  4. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Tian J, et al. Proc Natl Acad Sci U S A, 2005 Jul 26. PMID 16027371, Free PMC Article
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report effects of transposon and deletion mutants in Mycobacterium tuberculosis protein rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.
    Title: Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.
  2. Data indicate that GarA decreases the abundance of the product thiamin diphosphate (ThDP) adduct in the signal pathway of 2-hydroxy-3-oxoadipate synthase HOAS (encoded by Rv1248c, identified in PMID:20416504).
    Title: Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase.
  3. Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate, which decomposes to 5-hydroxylevulinate.
    Title: Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.
  4. alpha-ketoglutarate decarboxylase (Kgd)catalyzing reactions from alpha-ketoglutarate to succinic semialdehyde
    Title: Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
multifunctional 2-oxoglutarate dehydrogenase E1 component /2-oxoglutarate dehydrogenase dihydrolipoyllysine-residue succinyltransferase
NP_215764.2
  • Multifunctional alpha-ketoglutarate metabolic enzyme. Cofactor: thiamine diphosphate.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1389357..1393052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215764.2 multifunctional 2-oxoglutarate dehydrogenase E1 component /2-oxoglutarate dehydrogenase dihydrolipoyllysine-residue succinyltransferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215764.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A654T7N1
    Conserved Domains (1) summary
    PRK12270
    Location:5 → 1231
    kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIS5.1

Gene LinkOut

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Molecular Biology Databases
Research Materials