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ppsD phthiocerol synthesis polyketide synthase type I PpsD [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887172, updated on 11-Dec-2020

Summary

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Gene symbol
ppsD
Gene description
phthiocerol synthesis polyketide synthase type I PpsD
Locus tag
Rv2934
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3262248..3267731)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene fatty-acid--CoA ligase FadD26 Neighboring gene phthiocerol synthesis polyketide synthase type I PpsA Neighboring gene phthiocerol synthesis polyketide synthase type I PpsB Neighboring gene phthiocerol synthesis polyketide synthase type I PpsC Neighboring gene phthiocerol synthesis polyketide synthase type I PpsE Neighboring gene daunorubicin ABC transporter ATP-binding protein DrrA Neighboring gene daunorubicin ABC transporter permease DrrB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis. De Majumdar S, et al. BMC Genomics, 2019 Feb 12. PMID 30755157, Free PMC Article
  2. Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity. Kirksey MA, et al. Infect Immun, 2011 Jul. PMID 21576344, Free PMC Article
  3. Identification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosis. Siméone R, et al. J Bacteriol, 2007 Jul. PMID 17468241, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A spontaneous mutation in the ppsD gene of Comp1 strain underlies down-modulation of the phthiocerol dimycocerosate locus which is associated with defects in permeability and infectivity as well as virulence attenuation in guinea pigs.
    Title: Genome analysis identifies a spontaneous nonsense mutation in ppsD leading to attenuation of virulence in laboratory-manipulated Mycobacterium tuberculosis.
  2. a spontaneous point mutation in the putative polyketide synthase results in a G44C amino acid substitution responsible for PDIM deficiency, virulence attenuation in NOS2-neg and wild-type C57BL/6 mice, and a growth advantage in vitro in liquid culture.
    Title: Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity.
  3. Findings indicate that Rv2953 encodes a trans-acting enoyl reductase that acts with PpsD in phthiocerol and phenolphthiocerol biosynthesis.
    Title: Identification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
phthiocerol synthesis polyketide synthase type I PpsD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3262248..3267731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217450.1 phthiocerol synthesis polyketide synthase type I PpsD [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217450.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WQE3
    UniProtKB/TrEMBL
    I6YAM7
    Conserved Domains (3) summary
    cd08955
    Location:1323 → 1656
    KR_2_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x)
    smart00823
    Location:1696 → 1785
    PKS_PP; Phosphopantetheine attachment site
    COG3321
    Location:36 → 1097
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WQE3.1

Gene LinkOut

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Molecular Biology Databases