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papA5 phthiocerol/phthiodiolone dimycocerosyl transferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887327, updated on 6-Oct-2023

Summary

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Gene symbol
papA5
Gene description
phthiocerol/phthiodiolone dimycocerosyl transferase
Locus tag
Rv2939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3274949..3276217)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene daunorubicin ABC transporter ATP-binding protein DrrA Neighboring gene daunorubicin ABC transporter permease DrrB Neighboring gene daunorubicin ABC transporter permease DrrC Neighboring gene multifunctional mycocerosic acid synthase Neighboring gene long-chain-fatty-acid--AMP ligase FadD28 Neighboring gene transmembrane transport protein MmpL7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids. Touchette MH, et al. Biochemistry, 2015 Sep 8. PMID 26271001, Free PMC Article
  2. Mycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5. Onwueme KC, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070765, Free PMC Article
  3. Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosis. Gupta M, et al. J Biol Chem, 2009 Dec 11. PMID 19826007, Free PMC Article
  4. Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid. Trivedi OA, et al. Mol Cell, 2005 Mar 4. PMID 15749014
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PapA5 was identified as the terminal enzyme in dimycocerosates biosynthesis.
    Title: Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids.
  2. Data provides initial clues for a possible regulation of PapA5 and hence the phthiocerol dimycocerosate biosynthesis by PknB, either by direct phosphorylation of PapA5 or indirectly through Rv0019c.
    Title: Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosis.
  3. Mycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5
    Title: Mycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
phthiocerol/phthiodiolone dimycocerosyl transferase
NP_217455.1
  • polyketide synthase associated protein PapA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3274949..3276217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217455.1 phthiocerol/phthiodiolone dimycocerosyl transferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217455.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WB29
    Conserved Domains (1) summary
    PRK09294
    Location:1 → 421
    PRK09294; phthiocerol/phthiodiolone dimycocerosyl transferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIN5.1

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