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ARHGEF7 Rho guanine nucleotide exchange factor 7 [ Homo sapiens (human) ]

Gene ID: 8874, updated on 7-Apr-2024

Summary

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Official Symbol
ARHGEF7provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 7provided by HGNC
Primary source
HGNC:HGNC:15607
See related
Ensembl:ENSG00000102606 MIM:605477; AllianceGenome:HGNC:15607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314
Summary
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in brain (RPKM 14.7), fat (RPKM 11.2) and 25 other tissues See more
Orthologs
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Genomic context

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See ARHGEF7 in Genome Data Viewer
Location:
13q34
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (111114619..111305734)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (110344517..110535326)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111766966..111958081)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903213 Neighboring gene long intergenic non-protein coding RNA 431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8020 Neighboring gene Sharpr-MPRA regulatory region 12287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111704289-111704788 Neighboring gene NANOG hESC enhancer GRCh37_chr13:111716396-111716926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5526 Neighboring gene long intergenic non-protein coding RNA 368 Neighboring gene ARHGEF7 antisense RNA 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:111772850-111772988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5527 Neighboring gene uncharacterized LOC101060553 Neighboring gene ARHGEF7 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8026 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:111850373-111850578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111858211-111858712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111858713-111859212 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:111864035-111864562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111866216-111866751 Neighboring gene spalt like transcription factor 4 pseudogene 4 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:111867287-111867821 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:111932258-111933457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111948473-111948972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111967966-111968521 Neighboring gene uncharacterized LOC105370365 Neighboring gene testis expressed 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112041571-112042071 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112055149-112055694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112055695-112056240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112056241-112056784 Neighboring gene uncharacterized LOC107984618

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. AMPK phosphorylation of the β(1)Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells. Ho PY, et al. Am J Physiol Renal Physiol, 2019 Dec 1. PMID 31566435, Free PMC Article
  2. ARHGEF7 promotes metastasis of colorectal adenocarcinoma by regulating the motility of cancer cells. Lei X, et al. Int J Oncol, 2018 Nov. PMID 30132516, Free PMC Article
  3. Loss of β-PIX inhibits focal adhesion disassembly and promotes keratinocyte motility via myosin light chain activation. Hiroyasu S, et al. J Cell Sci, 2017 Jul 15. PMID 28596238, Free PMC Article
  4. β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration. Yu HW, et al. J Cell Mol Med, 2015 May. PMID 25683605, Free PMC Article
  5. The Cdc42/Rac nucleotide exchange factor protein β1Pix (Pak-interacting exchange factor) modulates β-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of β1PIX with β-catenin. Chahdi A, et al. J Biol Chem, 2013 Nov 22. PMID 24129564, Free PMC Article

See all (168) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.
    Title: SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.
  2. Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics.
    Title: Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics.
  3. ARHGEF7 (beta-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function.
    Title: ARHGEF7 (β-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function.
  4. Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.
    Title: Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.
  5. our results demonstrate the importance of AMPK-mediated phosphorylation of beta1Pix at Ser(71), which promotes 14-3-3 interactions with beta1Pix and Nedd4-2 to form a tripartite ENaC inhibitory complex, in the mechanism of ENaC regulation by AMPK
    Title: AMPK phosphorylation of the β(1)Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells.
  6. Expression of ARHGEF7 is significantly increased and associated with metastasis in colorectal adenocarcinoma.
    Title: ARHGEF7 promotes metastasis of colorectal adenocarcinoma by regulating the motility of cancer cells.
  7. Induced association of beta-PIX with GIT1 is essential for the stimulation of intestinal epithelial restitution by activating Rac1, and this signaling pathway is tightly regulated by cellular polyamines.
    Title: β-PIX plays an important role in regulation of intestinal epithelial restitution by interacting with GIT1 and Rac1 after wounding.
  8. Traction forces generated by beta-PIX knockdown cells are increased relative to those in control cells, a result consistent with an unexpected enhancement in the migration of single beta-PIX knockdown cells and monolayers of such cells. Authors propose that targeting beta-PIX might be a means of promoting epithelialization of wounds in vivo.
    Title: Loss of β-PIX inhibits focal adhesion disassembly and promotes keratinocyte motility via myosin light chain activation.
  9. S340E mutation enhances Nox1 activation (Kaito et al., 2014), the present study suggests that betaPix can also play an inhibitory role in O2(-) production, depending on the sites of phosphorylation.
    Title: Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.
  10. Data suggest that Scribble PDZ-domain-1 and PDZ-domain-3 are major domains that interact with beta-PIX and exhibit distinct binding hierarchy in interactions between individual Scribble PDZ domains and beta-PIX. (Scribble = scribbled planar cell polarity protein; beta-PIX = Rho guanine nucleotide exchange factor 7)
    Title: Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association meta-analysis for total serum bilirubin levels.
EBI GWAS Catalog
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
EBI GWAS Catalog
Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
EBI GWAS Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef In the presence of Nef, lipid raft Cdc42 is activated and forms a ternary complex between the c-Cbl-interacting protein p85Cool-1/betaPix and c-Cbl, displacing UbcH7 from rafts PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0142, KIAA0412, DKFZp761K1021, DKFZp686C12170

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in focal adhesion assembly HDA PubMed 
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity HMP PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fibroblast migration HDA PubMed 
involved_in positive regulation of lamellipodium morphogenesis HMP PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading HMP PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion HDA PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynapse ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 7
Names
PAK-interacting exchange factor beta
Rho guanine nucleotide exchange factor (GEF) 7
SH3 domain-containing proline-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113511.2 → NP_001106983.1  rho guanine nucleotide exchange factor 7 isoform c

    See identical proteins and their annotated locations for NP_001106983.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes isoform c.
    Source sequence(s)
    AB177848, AK093326, AL353704, BC060776, BM677392, DB180957
    Consensus CDS
    CCDS45068.1
    UniProtKB/Swiss-Prot
    B1ALK6, B1ALK8, Q14155, Q3LIA4, Q5W9H0, Q6P9G3, Q6PII2, Q86W63, Q8N3M1
    UniProtKB/TrEMBL
    A0A2X0SF98
    Related
    ENSP00000364893.2, ENST00000375741.6
    Conserved Domains (7) summary
    cd12061
    Location:188 → 241
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:272 → 449
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:480 → 578
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:634 → 732
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:138 → 184
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cl00030
    Location:21 → 128
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl26464
    Location:583 → 664
    Atrophin-1; Atrophin-1 family

  2. NM_001113512.2 → NP_001106984.1  rho guanine nucleotide exchange factor 7 isoform d

    See identical proteins and their annotated locations for NP_001106984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 3. The resulting protein (isoform d) is shorter than isoform c.
    Source sequence(s)
    AB177848, AK093326, AL353704, BC033905, BC060776, BM677392, DB180957
    Consensus CDS
    CCDS45069.1
    UniProtKB/TrEMBL
    A0A2X0SF98
    Related
    ENSP00000364891.2, ENST00000375739.6
    Conserved Domains (7) summary
    cd12061
    Location:138 → 191
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:21 → 75
    CH; Calponin homology domain
    cd00160
    Location:222 → 399
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:430 → 528
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:448 → 528
    PH; PH domain
    pfam16614
    Location:584 → 682
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:88 → 134
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  3. NM_001113513.2 → NP_001106985.1  rho guanine nucleotide exchange factor 7 isoform a

    See identical proteins and their annotated locations for NP_001106985.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AL390754, BC050521, CF121796, CF144155, D63476, DA216264
    Consensus CDS
    CCDS9521.1
    Related
    ENSP00000397068.2, ENST00000426073.6
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:557 → 643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  4. NM_001320851.2 → NP_001307780.1  rho guanine nucleotide exchange factor 7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AB177849, AL390754, BC050521, CF121796, CF144155, D63476, DA404477
    Consensus CDS
    CCDS9521.1
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:557 → 643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  5. NM_001320852.1 → NP_001307781.1  rho guanine nucleotide exchange factor 7 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (e) lacks a portion of the N-terminus and has a longer, distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS91837.1
    UniProtKB/TrEMBL
    A0A2X0SF98, A0A8V8TQ72
    Related
    ENSP00000514984.1, ENST00000700426.1
    Conserved Domains (8) summary
    cd12061
    Location:167 → 220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21 → 107
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:477 → 557
    PH; PH domain
    pfam16523
    Location:714 → 800
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:613 → 711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  6. NM_001320853.2 → NP_001307782.1  rho guanine nucleotide exchange factor 7 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (f) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AK300272, BC050521, CF121796, CF144155
    UniProtKB/TrEMBL
    B7Z6G2, Q5W9H1
    Conserved Domains (7) summary
    cd12061
    Location:85 → 138
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:169 → 346
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:377 → 475
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:395 → 475
    PH; PH domain
    pfam16523
    Location:632 → 718
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:531 → 629
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:35 → 81
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  7. NM_001320854.2 → NP_001307783.1  rho guanine nucleotide exchange factor 7 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (g) has a distinct, shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AK093326, AK295472, AK308897, BC060776, BM677392, DB180957
    Consensus CDS
    CCDS81781.1
    UniProtKB/TrEMBL
    B7Z344, E9PDQ5
    Related
    ENSP00000417596.1, ENST00000478679.5
    Conserved Domains (4) summary
    cd00160
    Location:16 → 193
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:224 → 322
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:242 → 322
    PH; PH domain
    pfam16614
    Location:378 → 476
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

  8. NM_001330597.2 → NP_001317526.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. It initiates translation at a downstream start codon. The resulting protein (isoform h) has a shorter N-terminus than isoform c. Variants 10, 11, and 22-26 all encode the same isoform (h).
    Source sequence(s)
    AB075521, AL139086, AL390754, AW872844, BC060776, D63476, DA404477
    Consensus CDS
    CCDS86362.1
    UniProtKB/TrEMBL
    B7Z344
    Conserved Domains (5) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  9. NM_001330598.2 → NP_001317527.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. It initiates translation at a downstream start codon. The resulting protein (isoform h) has a shorter N-terminus than isoform c. Variants 10, 11, and 22-26 all encode the same isoform (h).
    Source sequence(s)
    AB075521, AB177849, AL139086, AL390754, AW872844, BC060776, D63476, DA404477
    Consensus CDS
    CCDS86362.1
    UniProtKB/TrEMBL
    B7Z344
    Conserved Domains (5) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  10. NM_001354046.2 → NP_001340975.1  rho guanine nucleotide exchange factor 7 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) encodes the longest isoform (i).
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86360.1
    UniProtKB/TrEMBL
    A0A2R8YG42, A0A2X0SF98
    Related
    ENSP00000495631.1, ENST00000646102.2
    Conserved Domains (8) summary
    cd12061
    Location:167 → 220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21 → 107
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:773 → 859
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:613 → 711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cl26464
    Location:562 → 643
    Atrophin-1; Atrophin-1 family

  11. NM_001354047.1 → NP_001340976.1  rho guanine nucleotide exchange factor 7 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL139086, AL353704, AL390754
    UniProtKB/TrEMBL
    A0A2X0SF98
    Conserved Domains (6) summary
    cd12061
    Location:95 → 148
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    smart00033
    Location:21 → 96
    CH; Calponin homology domain
    cd00160
    Location:179 → 356
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:387 → 485
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:541 → 639
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:490 → 571
    Atrophin-1; Atrophin-1 family

  12. NM_001354048.1 → NP_001340977.1  rho guanine nucleotide exchange factor 7 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 15-17, encodes isoform k.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86361.1
    UniProtKB/TrEMBL
    B1ALK7
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:616 → 702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  13. NM_001354049.2 → NP_001340978.1  rho guanine nucleotide exchange factor 7 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 14, 16, and 17, encodes isoform k.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86361.1
    UniProtKB/TrEMBL
    B1ALK7
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:616 → 702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  14. NM_001354050.2 → NP_001340979.1  rho guanine nucleotide exchange factor 7 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 14, 15, and 17, encodes isoform k.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86361.1
    UniProtKB/TrEMBL
    B1ALK7
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:616 → 702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  15. NM_001354051.2 → NP_001340980.1  rho guanine nucleotide exchange factor 7 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 14-16, encodes isoform k.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86361.1
    UniProtKB/TrEMBL
    B1ALK7
    Related
    ENSP00000218789.5, ENST00000218789.9
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:616 → 702
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  16. NM_001354052.2 → NP_001340981.1  rho guanine nucleotide exchange factor 7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 1, 5, 6, and 19, encodes isoform a.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS9521.1
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:557 → 643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  17. NM_001354053.2 → NP_001340982.1  rho guanine nucleotide exchange factor 7 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 1, 5, 6, and 18, encodes isoform a.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS9521.1
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:557 → 643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  18. NM_001354054.2 → NP_001340983.1  rho guanine nucleotide exchange factor 7 isoform l

    Status: REVIEWED

    Source sequence(s)
    AL139086, AL353704, AL390754
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:569 → 655
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 566
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:407 → 490
    Atrophin-1; Atrophin-1 family

  19. NM_001354055.2 → NP_001340984.1  rho guanine nucleotide exchange factor 7 isoform m

    Status: REVIEWED

    Source sequence(s)
    AL139086
    UniProtKB/TrEMBL
    B7Z344
    Conserved Domains (5) summary
    cd00160
    Location:16 → 193
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:224 → 322
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:538 → 624
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:378 → 476
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:327 → 408
    Atrophin-1; Atrophin-1 family

  20. NM_001354056.1 → NP_001340985.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 10, 11, and 23-26, encodes isoform h.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86362.1
    UniProtKB/TrEMBL
    B7Z344
    Conserved Domains (5) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  21. NM_001354057.2 → NP_001340986.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 10, 11, 22, and 24-26, encodes isoform h.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86362.1
    UniProtKB/TrEMBL
    B7Z344
    Conserved Domains (5) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  22. NM_001354058.2 → NP_001340987.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 10, 11, 22, 23, 25, and 26, encodes isoform h.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86362.1
    UniProtKB/TrEMBL
    B7Z344
    Conserved Domains (5) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  23. NM_001354059.2 → NP_001340988.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 10, 11, 22-24, and 26, encodes isoform h.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86362.1
    UniProtKB/TrEMBL
    B7Z344
    Conserved Domains (5) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  24. NM_001354060.2 → NP_001340989.1  rho guanine nucleotide exchange factor 7 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 10, 11, and 22-25, encodes isoform h.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS86362.1
    UniProtKB/TrEMBL
    B7Z344
    Related
    ENSP00000364875.1, ENST00000375723.5
    Conserved Domains (5) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  25. NM_001354061.2 → NP_001340990.1  rho guanine nucleotide exchange factor 7 isoform n

    Status: REVIEWED

    Source sequence(s)
    AL139086
    UniProtKB/TrEMBL
    B7Z344
    Conserved Domains (4) summary
    cd00160
    Location:20 → 147
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:178 → 276
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16614
    Location:332 → 430
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:283 → 366
    Atrophin-1; Atrophin-1 family

  26. NM_003899.5 → NP_003890.1  rho guanine nucleotide exchange factor 7 isoform a

    See identical proteins and their annotated locations for NP_003890.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AL139086, AL353704, AL390754
    Consensus CDS
    CCDS9521.1
    Related
    ENSP00000364888.4, ENST00000375736.8
    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:557 → 643
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 554
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:405 → 486
    Atrophin-1; Atrophin-1 family

  27. NM_145735.3 → NP_663788.1  rho guanine nucleotide exchange factor 7 isoform b

    See identical proteins and their annotated locations for NP_663788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 3. The resulting protein (isoform b) is shorter than isoform c.
    Source sequence(s)
    AB177848, AK093326, AL353704, AL834228, BC060776, BM677392, DB180957
    Consensus CDS
    CCDS32009.1
    UniProtKB/TrEMBL
    A0A2X0SF98
    Related
    ENSP00000325994.5, ENST00000317133.9
    Conserved Domains (7) summary
    cd12061
    Location:167 → 220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21 → 107
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:477 → 557
    PH; PH domain
    pfam16614
    Location:613 → 711
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    111114619..111305734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430722.1 → XP_047286678.1  rho guanine nucleotide exchange factor 7 isoform X1

  2. XM_006719956.4 → XP_006720019.1  rho guanine nucleotide exchange factor 7 isoform X4

    UniProtKB/TrEMBL
    A0A2X0SF98
    Conserved Domains (8) summary
    cd12061
    Location:167 → 220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21 → 107
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:459 → 557
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:477 → 557
    PH; PH domain
    pfam16523
    Location:726 → 812
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:613 → 723
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    pfam16615
    Location:117 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

  3. XM_047430726.1 → XP_047286682.1  rho guanine nucleotide exchange factor 7 isoform X6

  4. XM_017020815.2 → XP_016876304.1  rho guanine nucleotide exchange factor 7 isoform X10

  5. XM_047430728.1 → XP_047286684.1  rho guanine nucleotide exchange factor 7 isoform X8

  6. XM_047430732.1 → XP_047286688.1  rho guanine nucleotide exchange factor 7 isoform X12

  7. XM_047430723.1 → XP_047286679.1  rho guanine nucleotide exchange factor 7 isoform X2

  8. XM_047430724.1 → XP_047286680.1  rho guanine nucleotide exchange factor 7 isoform X3

  9. XM_047430729.1 → XP_047286685.1  rho guanine nucleotide exchange factor 7 isoform X9

  10. XM_011521133.3 → XP_011519435.1  rho guanine nucleotide exchange factor 7 isoform X18

    Conserved Domains (5) summary
    cd12061
    Location:167 → 220
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00014
    Location:21 → 107
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00160
    Location:251 → 428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16615
    Location:117 → 163
    RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    cl17171
    Location:459 → 503
    PH-like; Pleckstrin homology-like domain

  11. XM_047430738.1 → XP_047286694.1  rho guanine nucleotide exchange factor 7 isoform X13

  12. XM_047430742.1 → XP_047286698.1  rho guanine nucleotide exchange factor 7 isoform X15

  13. XM_047430745.1 → XP_047286701.1  rho guanine nucleotide exchange factor 7 isoform X16

  14. XM_047430733.1 → XP_047286689.1  rho guanine nucleotide exchange factor 7 isoform X13

  15. XM_047430735.1 → XP_047286691.1  rho guanine nucleotide exchange factor 7 isoform X13

  16. XM_047430744.1 → XP_047286700.1  rho guanine nucleotide exchange factor 7 isoform X16

  17. XM_047430736.1 → XP_047286692.1  rho guanine nucleotide exchange factor 7 isoform X13

  18. XM_017020822.2 → XP_016876311.1  rho guanine nucleotide exchange factor 7 isoform X15

    Conserved Domains (6) summary
    cd12061
    Location:10 → 63
    SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
    cd00160
    Location:94 → 271
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01225
    Location:302 → 400
    PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    pfam16523
    Location:569 → 655
    betaPIX_CC; betaPIX coiled coil
    pfam16614
    Location:456 → 566
    RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
    cl26464
    Location:407 → 490
    Atrophin-1; Atrophin-1 family

  19. XM_047430741.1 → XP_047286697.1  rho guanine nucleotide exchange factor 7 isoform X14

    UniProtKB/TrEMBL
    B1ALK7

  20. XM_047430747.1 → XP_047286703.1  rho guanine nucleotide exchange factor 7 isoform X19

    Related
    ENSP00000418067.1, ENST00000466143.5

  21. XM_047430748.1 → XP_047286704.1  rho guanine nucleotide exchange factor 7 isoform X20

  22. XM_047430750.1 → XP_047286706.1  rho guanine nucleotide exchange factor 7 isoform X20

  23. XM_047430751.1 → XP_047286707.1  rho guanine nucleotide exchange factor 7 isoform X20

  24. XM_047430739.1 → XP_047286695.1  rho guanine nucleotide exchange factor 7 isoform X13

  25. XM_047430740.1 → XP_047286696.1  rho guanine nucleotide exchange factor 7 isoform X13

  26. XM_047430737.1 → XP_047286693.1  rho guanine nucleotide exchange factor 7 isoform X13

  27. XM_047430743.1 → XP_047286699.1  rho guanine nucleotide exchange factor 7 isoform X16

  28. XM_047430734.1 → XP_047286690.1  rho guanine nucleotide exchange factor 7 isoform X13

  29. XM_047430725.1 → XP_047286681.1  rho guanine nucleotide exchange factor 7 isoform X5

  30. XM_047430730.1 → XP_047286686.1  rho guanine nucleotide exchange factor 7 isoform X11

  31. XM_047430727.1 → XP_047286683.1  rho guanine nucleotide exchange factor 7 isoform X7

  32. XM_047430746.1 → XP_047286702.1  rho guanine nucleotide exchange factor 7 isoform X17

RNA

  1. XR_007063704.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    110344517..110535326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375112.1 → XP_054231087.1  rho guanine nucleotide exchange factor 7 isoform X1

  2. XM_054375115.1 → XP_054231090.1  rho guanine nucleotide exchange factor 7 isoform X4

  3. XM_054375116.1 → XP_054231091.1  rho guanine nucleotide exchange factor 7 isoform X6

  4. XM_054375120.1 → XP_054231095.1  rho guanine nucleotide exchange factor 7 isoform X10

  5. XM_054375118.1 → XP_054231093.1  rho guanine nucleotide exchange factor 7 isoform X8

  6. XM_054375122.1 → XP_054231097.1  rho guanine nucleotide exchange factor 7 isoform X12

  7. XM_054375113.1 → XP_054231088.1  rho guanine nucleotide exchange factor 7 isoform X2

  8. XM_054375114.1 → XP_054231089.1  rho guanine nucleotide exchange factor 7 isoform X3

  9. XM_054375119.1 → XP_054231094.1  rho guanine nucleotide exchange factor 7 isoform X9

  10. XM_054375138.1 → XP_054231113.1  rho guanine nucleotide exchange factor 7 isoform X18

  11. XM_054375128.1 → XP_054231103.1  rho guanine nucleotide exchange factor 7 isoform X13

  12. XM_054375132.1 → XP_054231107.1  rho guanine nucleotide exchange factor 7 isoform X15

  13. XM_054375136.1 → XP_054231111.1  rho guanine nucleotide exchange factor 7 isoform X16

  14. XM_054375123.1 → XP_054231098.1  rho guanine nucleotide exchange factor 7 isoform X13

  15. XM_054375125.1 → XP_054231100.1  rho guanine nucleotide exchange factor 7 isoform X13

  16. XM_054375135.1 → XP_054231110.1  rho guanine nucleotide exchange factor 7 isoform X16

  17. XM_054375126.1 → XP_054231101.1  rho guanine nucleotide exchange factor 7 isoform X13

  18. XM_054375133.1 → XP_054231108.1  rho guanine nucleotide exchange factor 7 isoform X15

  19. XM_054375131.1 → XP_054231106.1  rho guanine nucleotide exchange factor 7 isoform X14

    UniProtKB/TrEMBL
    B1ALK7

  20. XM_054375139.1 → XP_054231114.1  rho guanine nucleotide exchange factor 7 isoform X19

  21. XM_054375140.1 → XP_054231115.1  rho guanine nucleotide exchange factor 7 isoform X20

  22. XM_054375141.1 → XP_054231116.1  rho guanine nucleotide exchange factor 7 isoform X20

  23. XM_054375142.1 → XP_054231117.1  rho guanine nucleotide exchange factor 7 isoform X20

  24. XM_054375127.1 → XP_054231102.1  rho guanine nucleotide exchange factor 7 isoform X13

  25. XM_054375134.1 → XP_054231109.1  rho guanine nucleotide exchange factor 7 isoform X16

  26. XM_054375130.1 → XP_054231105.1  rho guanine nucleotide exchange factor 7 isoform X13

  27. XM_054375129.1 → XP_054231104.1  rho guanine nucleotide exchange factor 7 isoform X13

  28. XM_054375124.1 → XP_054231099.1  rho guanine nucleotide exchange factor 7 isoform X13

  29. XM_054375121.1 → XP_054231096.1  rho guanine nucleotide exchange factor 7 isoform X11

  30. XM_054375117.1 → XP_054231092.1  rho guanine nucleotide exchange factor 7 isoform X7

  31. XM_054375137.1 → XP_054231112.1  rho guanine nucleotide exchange factor 7 isoform X17

RNA

  1. XR_008488792.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14155.2 GenPept UniProtKB/Swiss-Prot:Q14155

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