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aroK shikimate kinase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887434, updated on 11-Dec-2020

Summary

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Gene symbol
aroK
Gene description
shikimate kinase
Locus tag
Rv2539c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2862673..2863203, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene transmembrane protein Neighboring gene 3-dehydroquinate dehydratase Neighboring gene 3-dehydroquinate synthase Neighboring gene chorismate synthase Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone. Simithy J, et al. Biochim Biophys Acta Proteins Proteom, 2018 May-Jun. PMID 29654976
  2. The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses. Rosado LA, et al. PLoS One, 2013. PMID 23671579, Free PMC Article
  3. Mechanism of phosphoryl transfer catalyzed by shikimate kinase from Mycobacterium tuberculosis. Hartmann MD, et al. J Mol Biol, 2006 Dec 1. PMID 17020768
  4. Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid. Pereira JH, et al. Acta Crystallogr D Biol Crystallogr, 2004 Dec. PMID 15583379
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ilimaquinone irreversibly inhibits Mycobacterium tuberculosis shikimate kinase.
    Title: Mechanism of irreversible inhibition of Mycobacterium tuberculosis shikimate kinase by ilimaquinone.
  2. Biochemical and biophysical data suggest that the chemical reaction catalyzed by monomeric MtSK follows a rapid-equilibrium random order of substrate binding, and ordered product release.
    Title: The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses.
  3. There is a synergic mechanism by which binding of the first substrate to shikimate kinase may enhance the affinity for the second substrate.
    Title: Mechanism of phosphoryl transfer catalyzed by shikimate kinase from Mycobacterium tuberculosis.
  4. analysis of binding of shikimic acid to shikimate kinase from Mycobacterium tuberculosis by x-ray crystallography
    Title: Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
shikimate kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2862673..2863203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217055.1 shikimate kinase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217055.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WPY3
    UniProtKB/TrEMBL
    I6XEJ5
    Conserved Domains (1) summary
    PRK00131
    Location:1 → 167
    aroK; shikimate kinase; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WPY3.1

Gene LinkOut

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