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guaB2 inosine-5'-monophosphate dehydrogenase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887498, updated on 6-Oct-2023

Summary

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Gene symbol
guaB2
Gene description
inosine-5'-monophosphate dehydrogenase
Locus tag
Rv3411c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3829930..3831519, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene cholesterol oxidase Neighboring gene oxidoreductase Neighboring gene hypothetical protein Neighboring gene anti-sigma-D factor RsdA Neighboring gene ECF RNA polymerase sigma factor SigD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen. Cox JA, et al. Sci Rep, 2016 Dec 16. PMID 27982051, Free PMC Article
  2. Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis. Usha V, et al. Microbiology (Reading), 2011 Jan. PMID 21081761
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen.
    Title: Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen.
  2. Purified recombinant GuaB2, which uses inosine monophosphate as a substrate, was identified as the only active GuaB orthologue in Mycobacterium tuberculosis and showed optimal activity at pH 8.5 and 37 degrees C.
    Title: Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
inosine-5'-monophosphate dehydrogenase
NP_217928.1
  • imp dehydrogenase (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3829930..3831519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217928.1 inosine-5'-monophosphate dehydrogenase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217928.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3LEK6
    Conserved Domains (1) summary
    PRK05567
    Location:37 → 529
    PRK05567; inosine 5'-monophosphate dehydrogenase; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WKI7.1

Gene LinkOut

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Molecular Biology Databases