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iscS cysteine desulfurase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887677, updated on 4-Apr-2024

Summary

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Gene symbol
iscS
Gene description
cysteine desulfurase
Locus tag
Rv3025c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
nifS
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Genomic context

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Sequence:
NC_000962.3 (3383885..3385066, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene PE family protein PE29 Neighboring gene transposase Neighboring gene tRNA-specific 2-thiouridylase Neighboring gene hypothetical protein Neighboring gene GCN5-like N-acetyltransferase Neighboring gene electron transfer flavoprotein subunit alpha

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence. Rybniker J, et al. Biochem J, 2014 May 1. PMID 24548275
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cysteine desulfurase (IscS)-mediated fine-tuning of bioenergetics and SUF expression prevents Mycobacterium tuberculosis hypervirulence.
    Title: Cysteine desulfurase (IscS)-mediated fine-tuning of bioenergetics and SUF expression prevents Mycobacterium tuberculosis hypervirulence.
  2. Data from deletion mutants suggest that iscS is involved with iron-sulfur cluster assembly; crystal structure of iscS appears to serve as a model of evolutionary adaptations in response to deletions in the iron-sulfur operon.
    Title: The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
cysteine desulfurase
NP_217541.1
  • NIFS protein homolog (nitrogenase metalloclusters biosynthesis protein NIFS)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3383885..3385066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217541.1 cysteine desulfurase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217541.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4MHU3
    Conserved Domains (1) summary
    COG1104
    Location:1 → 376
    NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WQ71.1

Gene LinkOut

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Molecular Biology Databases