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fas fatty acid synthase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887704, updated on 11-Dec-2020

Summary

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Gene symbol
fas
Gene description
fatty acid synthase
Locus tag
Rv2524c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2840123..2849332, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene peroxiredoxin Neighboring gene holo-ACP synthase Neighboring gene hypothetical protein Neighboring gene antitoxin VapB17 Neighboring gene ribonuclease VapC17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation. Molle V, et al. J Biol Chem, 2006 Oct 6. PMID 16873379
  2. Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex. Ciccarelli L, et al. Structure, 2013 Jul 2. PMID 23746808
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The barrel-like structure of Mycobacterium tuberculosis FAS is not just a static scaffold for the catalytic domains, but may play an active role in coordinating fatty acid synthesis.
    Title: Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
  2. Ser/Thr protein kinase substrates are identified in M. tuberculosis that form part of the type II fatty acid synthase system involved in mycolic acid biosynthesis.
    Title: The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
fatty acid synthase
NP_217040.1
  • Fas (fatty acid synthetase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2840123..2849332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217040.1 fatty acid synthase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217040.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A089S8C7, P95029
    Conserved Domains (5) summary
    COG0304
    Location:2600 → 2992
    FabB; 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    COG0331
    Location:1329 → 1722
    FabD; Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]
    COG4981
    Location:384 → 1090
    COG4981; Enoyl reductase domain of yeast-type FAS1 [Lipid transport and metabolism]
    COG4982
    Location:1743 → 2585
    FabG2; 3-oxoacyl-ACP reductase domain of yeast-type FAS1 [Lipid transport and metabolism]
    cd03447
    Location:1211 → 1330
    FAS_MaoC; the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD).
Nucleotide Protein
Heading Accession and Version

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