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ispD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887787, updated on 6-Oct-2023

Summary

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Gene symbol
ispD
Gene description
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Locus tag
Rv3582c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (4024344..4025039, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB Neighboring gene cysteine--tRNA ligase Neighboring gene 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Neighboring gene RNA polymerase-binding transcription factor CarD Neighboring gene lipoprotein LpqE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional studies of mycobacterial IspD enzymes. Björkelid C, et al. Acta Crystallogr D Biol Crystallogr, 2011 May. PMID 21543842
  2. Homology modeling of Mycobacterium tuberculosis 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase, the third enzyme in the MEP pathway for isoprenoid biosynthesis. Obiol-Pardo C, et al. J Mol Model, 2010 Jun. PMID 19916033
  3. Biosynthesis of isoprenoids: characterization of a functionally active recombinant 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) from Mycobacterium tuberculosis H37Rv. Shi W, et al. J Biochem Mol Biol, 2007 Nov 30. PMID 18047786
  4. Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development. Eoh H, et al. J Bacteriol, 2007 Dec. PMID 17921290, Free PMC Article
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This paper presents initial structural and functional studies on ispD from both M. tuberculosis and M. smegmatis; the two proteins share 64% sequence identity with each other.
    Title: Structural and functional studies of mycobacterial IspD enzymes.
  2. Data show that the metal coordination of CDP-methylerythritol in 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase (CMS) differs substantially with respect to the Escherichia coli variant.
    Title: Homology modeling of Mycobacterium tuberculosis 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase, the third enzyme in the MEP pathway for isoprenoid biosynthesis.
  3. IspD exists as a homodimer with an apparent molecular mass of 52 kDa. IspD has high specificity for pyrimidine bases and narrow divalent cation requirements, with maximal activity found in the presence of CTP and Mg(2+).
    Title: Biosynthesis of isoprenoids: characterization of a functionally active recombinant 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) from Mycobacterium tuberculosis H37Rv.
  4. Rv3582c is essential for M. tuberculosis.
    Title: Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
NP_218099.1
  • 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD; MEP cytidylyltransferase (MCT)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4024344..4025039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218099.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218099.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WD01
    Conserved Domains (1) summary
    pfam01128
    Location:10 → 230
    IspD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3OKR_A.1
3OKR_B.1
3OKR_C.1
3OKR_D.1
P9WKG9.1

Gene LinkOut

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