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dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887800, updated on 6-Oct-2023

Summary

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Gene symbol
dxr
Gene description
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Locus tag
Rv2870c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
ispC
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Genomic context

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Sequence:
NC_000962.3 (3181770..3183011, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) Neighboring gene zinc metalloprotease Neighboring gene antitoxin VapB43 Neighboring gene ribonuclease VapC43 Neighboring gene cell surface lipoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that IspC (1-deoxy-D-xylulose 5-phosphate reductoisomerase) displays a high level of enantioselectivity for an alpha-substituted fosmidomycin derivative.
    Title: IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters.
  2. Overexpression of dxs1 or dxs2 was inhibitory to growth, whereas overexpression of dxr or gcpE was not.
    Title: The nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by Dxs.
  3. The crystal structure of the enzyme shows that a sulfate is bound at the expected site of the phosphate moiety of the sugar substrate, and the structure represents an intermediate conformation between the open apo form and the closed holo form.
    Title: The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target.
  4. enzymatic properties and fosfidomycin sensitivity of recombinant Rv2780c were characterized
    Title: 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
1-deoxy-D-xylulose 5-phosphate reductoisomerase
NP_217386.2
  • Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomerase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3181770..3183011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217386.2 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217386.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E8B709, A0A0H3LD31, A0A0K2HZP2, A0A109SZG8, A0A7U4FB37
    Conserved Domains (1) summary
    PRK05447
    Location:14 → 391
    PRK05447; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2C82_A.1
2C82_B.1
P9WNS1.1

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Research Materials