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relA bifunctional (p)ppGpp synthase/hydrolase RelA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887888, updated on 4-Apr-2024

Summary

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Gene symbol
relA
Gene description
bifunctional (p)ppGpp synthase/hydrolase RelA
Locus tag
Rv2583c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2907826..2910198, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene histidine--tRNA ligase Neighboring gene glyoxalase II Neighboring gene peptidyl-prolyl cis-trans isomerase B Neighboring gene adenine phosphoribosyltransferase Neighboring gene lipoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and preliminary characterization of four Rel homologues from pathogenic bacteria: Implications for species-specific inhibitor design. Hegde V, et al. Protein Expr Purif, 2021 Jan. PMID 33002609
  2. Functional regulation of the opposing (p)ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis. Avarbock A, et al. Biochemistry, 2005 Jul 26. PMID 16026164
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Purification and preliminary characterization of four Rel homologues from pathogenic bacteria: Implications for species-specific inhibitor design.
    Title: Purification and preliminary characterization of four Rel homologues from pathogenic bacteria: Implications for species-specific inhibitor design.
  2. Purified functional synthesis and hydrolysis fragments of bifunctional RelA demonstrate distinct active sites; RelA carboxyl-terminus is an important region for multimerization and regulation of (p)ppGpp synthesis and hydrolysis
    Title: Functional regulation of the opposing (p)ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
bifunctional (p)ppGpp synthase/hydrolase RelA
NP_217099.1
  • ATP:GTP 3'-pyrophosphotransferase (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2907826..2910198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217099.1 bifunctional (p)ppGpp synthase/hydrolase RelA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217099.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0U0QHY2
    Conserved Domains (1) summary
    TIGR00691
    Location:86 → 785
    spoT_relA; (p)ppGpp synthetase, RelA/SpoT family
Nucleotide Protein
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