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Rv2212 adenylyl cyclase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887979, updated on 6-Oct-2023

Summary

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Gene symbol
Rv2212
Gene description
adenylyl cyclase
Locus tag
Rv2212
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2477190..2478326)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene integral membrane protein Neighboring gene branched-chain amino acid aminotransferase Neighboring gene aminomethyltransferase Neighboring gene cytosol aminopeptidase Neighboring gene oxidoreductase EphD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The adenylyl cyclase Rv2212 modifies the proteome and infectivity of Mycobacterium bovis BCG. Pedroza-Roldán C, et al. Folia Microbiol (Praha), 2015 Jan. PMID 25038956
  2. Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv. Abdel Motaal A, et al. FEBS J, 2006 Sep. PMID 16925585
  3. Interaction of Erp Protein of Mycobacterium tuberculosis with Rv2212 Enhances Intracellular Survival of Mycobacterium smegmatis. Ganaie AA, et al. J Bacteriol, 2016 Oct 15. PMID 27481930, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study describes a novel function of RvErp protein by identifying Rv2212 as its interacting protein.
    Title: Interaction of Erp Protein of Mycobacterium tuberculosis with Rv2212 Enhances Intracellular Survival of Mycobacterium smegmatis.
  2. Hsp60-driven expression of Rv2212 resulted in an increased of replication in murine macrophages but an attenuated phenotype in lungs and spleen.
    Title: The adenylyl cyclase Rv2212 modifies the proteome and infectivity of Mycobacterium bovis BCG.
  3. unsaturated fatty acids strongly stimulated Rv2212 activity by increasing substrate affinity; fatty acids greatly enhanced the pH sensitivity of the holoenzyme, thus converting Rv2212 to a pH sensor adenylyl cyclase
    Title: Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
adenylyl cyclase
NP_216728.1
  • ATP pyrophosphate-lyase, adenylate cyclase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2477190..2478326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216728.1 adenylyl cyclase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216728.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3LAY9
    Conserved Domains (2) summary
    cd07302
    Location:209 → 360
    CHD; cyclase homology domain
    pfam16701
    Location:8 → 138
    Ad_Cy_reg; Adenylate cyclase regulatory domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMU7.1

Gene LinkOut

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Molecular Biology Databases