U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

icd1 isocitrate dehydrogenase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888013, updated on 6-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
icd1
Gene description
isocitrate dehydrogenase
Locus tag
Rv3339c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000962.3 (3724615..3725844, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene tryptophan--tRNA ligase Neighboring gene pseudo Neighboring gene O-acetylhomoserine sulfhydrylase Neighboring gene homoserine O-acetyltransferase Neighboring gene methyltransferase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that ICDH enzymatic activity is reduced by Rv2170 protein which modifies its lysine residues post-transnationally.
    Title: Novel protein acetyltransferase, Rv2170, modulates carbon and energy metabolism in Mycobacterium tuberculosis.
  2. Structure of ICDH-1 to 2.18 A by X-ray crystallography with NADPH and Mn(2+) bound is a homodimer in which each subunit has a Rossmann fold, and a common top domain of interlocking beta sheets.
    Title: Structural, kinetic and chemical mechanism of isocitrate dehydrogenase-1 from Mycobacterium tuberculosis.
  3. Data show that inactivation of ICD1 by phosphorylation similar to E. coli ICD is important to open up the shunt pathway in the TCA cycle.
    Title: Determination of phosphorylation sites for NADP-specific isocitrate dehydrogenase from mycobacterium tuberculosis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
isocitrate dehydrogenase
NP_217856.1
  • NADP Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3724615..3725844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217856.1 isocitrate dehydrogenase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217856.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WCA2, R4M716
    Conserved Domains (1) summary
    PRK08299
    Location:5 → 407
    PRK08299; NADP-dependent isocitrate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WKL1.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases