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cyp142 cytochrome P450 monooxygenase Cyp142 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888282, updated on 6-Oct-2023

Summary

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Gene symbol
cyp142
Gene description
cytochrome P450 monooxygenase Cyp142
Locus tag
Rv3518c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3954325..3955521, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene enoyl-CoA hydratase EchA19 Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene coenzyme F420-dependent oxidoreductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. Driscoll MD, et al. J Biol Chem, 2010 Dec 3. PMID 20889498, Free PMC Article
  2. Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide. Ouellet H, et al. Biochemistry, 2009 Feb 10. PMID 19146393, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CYP142 is revealed as a cholesterol 27-oxidase with likely roles in host response modulation and cholesterol metabolism.
    Title: Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
  2. Reactive nitrogen species (*NO) produced by host macrophages binds to CYP125 in its ferric state; a role for *NO in inhibition of cytochrome P450 activities in dormant mycobacterial cells is conceivable.
    Title: Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
cytochrome P450 monooxygenase Cyp142

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3954325..3955521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218035.1 cytochrome P450 monooxygenase Cyp142 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218035.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3LM48
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2XKR_A.1
P9WPL5.1

Gene LinkOut

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Molecular Biology Databases