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glnA1 glutamine synthetase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888383, updated on 6-Oct-2023

Summary

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Gene symbol
glnA1
Gene description
glutamine synthetase
Locus tag
Rv2220
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
glnA
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Genomic context

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Sequence:
NC_000962.3 (2487615..2489051)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene transmembrane protein Neighboring gene membrane protein Neighboring gene [glutamate--ammonia-ligase] adenylyltransferase Neighboring gene glutamine synthetase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methionine sulfoximine resistance in Mycobacterium tuberculosis is due to a single nucleotide deletion resulting in increased expression of the major glutamine synthetase, GlnA1. Carroll P, et al. Microb Drug Resist, 2011 Sep. PMID 21875360, Free PMC Article
  2. Characterization of protein acyltransferase function of recombinant purified GlnA1 from Mycobacterium tuberculosis: a moon lighting property. Baghel AS, et al. Microbiol Res, 2011 Dec 20. PMID 21411303
  3. All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis. Harth G, et al. Mol Microbiol, 2005 Nov. PMID 16262797
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. All resistant strains had a single-nucleotide deletion in the 5' region of glnA1.
    Title: Methionine sulfoximine resistance in Mycobacterium tuberculosis is due to a single nucleotide deletion resulting in increased expression of the major glutamine synthetase, GlnA1.
  2. These results appropriately characterize glutamine synthetase of Mycobacterium tuberculosis exhibiting transacylase action as a moonlighting protein.
    Title: Characterization of protein acyltransferase function of recombinant purified GlnA1 from Mycobacterium tuberculosis: a moon lighting property.
  3. fndings show that only glnA1 of the four glutamine synthetase genes is required for in vitro growth of M. tuberculosis and all four glutamine synthetase genes are transcribed but only GlnA1 is produced in microgram quantities in M. tuberculosis cultures
    Title: All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
glutamine synthetase
NP_216736.1
  • glnA1, glutamine synthetase class I

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2487615..2489051
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216736.1 glutamine synthetase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216736.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W9B9
    Conserved Domains (1) summary
    TIGR00653
    Location:7 → 477
    GlnA; glutamine synthetase, type I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WN39.1

Gene LinkOut

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