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lipF carboxylesterase LipF [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888430, updated on 4-Apr-2024

Summary

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Gene symbol
lipF
Gene description
carboxylesterase LipF
Locus tag
Rv3487c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3906174..3907007, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene short-chain type dehydrogenase/reductase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene trehalose-phosphate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LipF increases rifampicin and streptomycin sensitivity in a Mycobacterium tuberculosis surrogate. Arriaga-Guerrero AL, et al. BMC Microbiol, 2020 May 25. PMID 32450809, Free PMC Article
  2. Mutational analysis of the -10 region from the Mycobacterium tuberculosis lipF promoter. Gonzales M, et al. Mol Biol Rep, 2009 Jul. PMID 18649013
  3. Functional characterization of the phospholipase C activity of Rv3487c and its localization on the cell wall of Mycobacterium tuberculosis. Srinivas M, et al. J Biosci, 2008 Jun. PMID 18535356
  4. The lipF promoter of Mycobacterium tuberculosis is upregulated specifically by acidic pH but not by other stress conditions. Richter L, et al. Microbiol Res, 2009. PMID 17869077, Free PMC Article
  5. Determination of the minimal acid-inducible promoter region of the lipF gene from Mycobacterium tuberculosis. Richter L, et al. Gene, 2007 Jun 15. PMID 17434691

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LipF increases rifampicin and streptomycin sensitivity in a Mycobacterium tuberculosis surrogate.
    Title: LipF increases rifampicin and streptomycin sensitivity in a Mycobacterium tuberculosis surrogate.
  2. investigate the -10 region of the lipF promoter
    Title: Mutational analysis of the -10 region from the Mycobacterium tuberculosis lipF promoter.
  3. lipF promoter is upregulated by acidic stress.
    Title: The lipF promoter of Mycobacterium tuberculosis is upregulated specifically by acidic pH but not by other stress conditions.
  4. M.tuberculosis possesses an additional cell wall-associated protein, Rv3487c, with phospholipase C activity.
    Title: Functional characterization of the phospholipase C activity of Rv3487c and its localization on the cell wall of Mycobacterium tuberculosis.
  5. A minimal acid-inducible promoter region was identified and is located between -515 bp and -573 bp with respect to the start site of translation of lipF.
    Title: Determination of the minimal acid-inducible promoter region of the lipF gene from Mycobacterium tuberculosis.
  6. Rv3487c was cloned and expressed in Escherichia coli, and the catalytic triad of Rv3487c consists of residues Ser90, Glu189, and His219 as demonstrated by amino acid sequence alignment, three-dimensional modeling, and site-directed mutagenesis.
    Title: Expression and characterization of the carboxyl esterase Rv3487c from Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
carboxylesterase LipF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3906174..3907007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218004.3 carboxylesterase LipF [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218004.3

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3LM13
    Conserved Domains (1) summary
    COG0657
    Location:6 → 247
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O06350.3

Gene LinkOut

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