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mutT2 8-oxo-dGTP diphosphatase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888485, updated on 6-Oct-2023

Summary

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Gene symbol
mutT2
Gene description
8-oxo-dGTP diphosphatase
Locus tag
Rv1160
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1286595..1287020)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol pentamannoside mannosyltransferase Neighboring gene 4a-hydroxytetrahydrobiopterin dehydratase Neighboring gene nitrate reductase subunit alpha Neighboring gene nitrate reductase subunit beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into the specificity and catalytic mechanism of mycobacterial nucleotide pool sanitizing enzyme MutT2. Singh A, et al. J Struct Biol, 2018 Dec. PMID 30312643
  2. Biochemical properties of MutT2 proteins from Mycobacterium tuberculosis and M. smegmatis and their contrasting antimutator roles in Escherichia coli. Sang PB, et al. J Bacteriol, 2013 Apr. PMID 23354752, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that pyrophosphatases MutT2 hydrolyzes 5methyl-dCTP and 8-oxo-dGTP to their respective monophosphate products.
    Title: Structural insights into the specificity and catalytic mechanism of mycobacterial nucleotide pool sanitizing enzyme MutT2.
  2. Distinct from the Escherichia coli MutT, which hydrolyzes 8-oxo-dGTP and 8-oxo-GTP, the mycobacterial MutT2 proteins hydrolyze not only 8-oxo-dGTP and 8-oxo-GTP but also dCTP and 5-methyl-dCTP.
    Title: Biochemical properties of MutT2 proteins from Mycobacterium tuberculosis and M. smegmatis and their contrasting antimutator roles in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
8-oxo-dGTP diphosphatase
NP_215676.1
  • mutator protein MutT; 7,8-dihydro-8-oxoguanine-triphosphatase (8-oxo-dGTPase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1286595..1287020
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215676.1 8-oxo-dGTP diphosphatase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215676.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A109SVJ0
    Conserved Domains (1) summary
    cd03425
    Location:6 → 127
    MutT_pyrophosphohydrolase; The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIY1.1

Gene LinkOut

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Molecular Biology Databases