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manB D-alpha-D-mannose-1-phosphate guanylyltransferase ManB [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888715, updated on 6-Oct-2023

Summary

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Gene symbol
manB
Gene description
D-alpha-D-mannose-1-phosphate guanylyltransferase ManB
Locus tag
Rv3264c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
hddC
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Genomic context

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Sequence:
NC_000962.3 (3644898..3645977, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 2-phospho-L-lactate transferase Neighboring gene coenzyme F420:L-glutamate ligase Neighboring gene DNA methylase Neighboring gene N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase Neighboring gene dTDP-4-dehydrorhamnose reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis and enzyme characterization of mannose-1-phosphate guanylyl transferase (ManB) from Mycobacterium tuberculosis. Taj A, et al. Res Microbiol, 2022 Jan-Feb. PMID 34644596
  2. Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages. McCarthy TR, et al. Mol Microbiol, 2005 Nov. PMID 16238626
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional analysis and enzyme characterization of mannose-1-phosphate guanylyl transferase (ManB) from Mycobacterium tuberculosis.
    Title: Functional analysis and enzyme characterization of mannose-1-phosphate guanylyl transferase (ManB) from Mycobacterium tuberculosis.
  2. Data suggest that manB encodes a functional phosphomannomutase involved in the biosynthesis of mannosylated lipoglycans that participate in the association of mycobacteria with macrophage phagocytic receptors.
    Title: Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
D-alpha-D-mannose-1-phosphate guanylyltransferase ManB
YP_177951.1
  • D-alpha-D-heptose-1-phosphate guanylyltransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3644898..3645977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177951.1 D-alpha-D-mannose-1-phosphate guanylyltransferase ManB [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177951.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E7X8D3, A0A120IQ91
    Conserved Domains (1) summary
    COG1208
    Location:5 → 355
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
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