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birA bifunctional biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888726, updated on 4-Feb-2024

Summary

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Gene symbol
birA
Gene description
bifunctional biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase
Locus tag
Rv3279c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3661212..3662012, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 5-(carboxyamino)imidazole ribonucleotide mutase Neighboring gene 5-(carboxyamino)imidazole ribonucleotide synthase Neighboring gene transmembrane protein Neighboring gene transmembrane protein Neighboring gene propionyl-CoA carboxylase subunit beta Neighboring gene bifunctional protein acetyl-/propionyl-CoAcarboxylase subunit epsilon AccE Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural ordering of disordered ligand-binding loops of biotin protein ligase into active conformations as a consequence of dehydration. Gupta V, et al. PLoS One, 2010 Feb 15. PMID 20169168, Free PMC Article
  2. Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosis. Purushothaman S, et al. PLoS One, 2008 May 28. PMID 18509457, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data provide answers to the reported lower affinities of Mtb-BirA toward ATP and biotin substrates.
    Title: Structural ordering of disordered ligand-binding loops of biotin protein ligase into active conformations as a consequence of dehydration.
  2. These studies thus open up avenues for understanding the unique features of MtBPL and the role it plays in biotin utilization in M. tuberculosis
    Title: Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
bifunctional biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3661212..3662012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217796.1 bifunctional biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217796.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A655AQH7
    Conserved Domains (1) summary
    COG0340
    Location:33 → 266
    BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3L1A_A.1
3L1A_B.1
3L2Z_A.1
3L2Z_B.1

Gene LinkOut

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Molecular Biology Databases
Research Materials