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ggt gamma-glutamyltransferase [ Helicobacter pylori 26695 ]

Gene ID: 899655, discontinued on 23-Mar-2020
  • This record was discontinued.

Summary

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Gene symbol
ggt
Gene description
gamma-glutamyltransferase
Locus tag
HP_RS05490
Gene type
protein coding
Organism
Helicobacter pylori 26695 (strain: 26695)
Lineage
Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter
Old locus tag
HP1118; HP_1118
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000915.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GGT is an important virulence factor and a promising target in the management of H. pylori-associated gastric diseases.
    Title: Instrumental Role of Helicobacter pylori γ-Glutamyl Transpeptidase in VacA-Dependent Vacuolation in Gastric Epithelial Cells.
  2. The results of this study indicated that the loss of survivin due to Helicobacter pylori infection involves proteasome-mediated degradation of the protein induced by secreted bacterial gamma-glutamyl transpeptidase.
    Title: Helicobacter pylori-induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma-glutamyl transpeptidase activity.
  3. It was suggested that Helicobacter pylori GGT is constitutively expressed under various conditions.
    Title: Profile of Expression of Helicobacter pylori gamma-glutamyltranspeptidase.
  4. The authors showed that Hp-DcuA, the fourth component of these novel deamidase-transport systems, was as crucial as Hp-gammaGT, Hp-AnsB, and Hp-GltS for animal model colonization.
    Title: Coupled amino acid deamidase-transport systems essential for Helicobacter pylori colonization.
  5. C-terminus of GT is critical for its autoprocessing and catalysis activity.
    Title: Crystal structure of acivicin-inhibited gamma-glutamyltranspeptidase reveals critical roles for its C-terminus in autoprocessing and catalysis.
  6. analysis of the enzymatic and autoprocessing activities of Helicobacter pylori gamma-glutamyltranspeptidase
    Title: Uncoupling the enzymatic and autoprocessing activities of Helicobacter pylori gamma-glutamyltranspeptidase.
  7. These observations show that one of the principle physiological functions of H. pylori GGT is to enable H. pylori cells to utilize extracellular glutamine and glutathione as a source of glutamate.
    Title: Metabolism of glutamine and glutathione via gamma-glutamyltranspeptidase and glutamate transport in Helicobacter pylori: possible significance in the pathophysiology of the organism.
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General protein information

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Preferred Names
gamma-glutamyltransferase
WP_001254471.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000915.1 Reference assembly

    Range
    1182706..1184409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_001254471.1 gamma-glutamyltransferase [Helicobacter pylori]

    See identical proteins and their annotated locations for WP_001254471.1

Nucleotide Protein
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