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PIAS2 protein inhibitor of activated STAT 2 [ Homo sapiens (human) ]

Gene ID: 9063, updated on 11-Apr-2024

Summary

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Official Symbol
PIAS2provided by HGNC
Official Full Name
protein inhibitor of activated STAT 2provided by HGNC
Primary source
HGNC:HGNC:17311
See related
Ensembl:ENSG00000078043 MIM:603567; AllianceGenome:HGNC:17311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4
Summary
This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
Expression
Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See PIAS2 in Genome Data Viewer
Location:
18q21.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (46803218..46920145, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (46993864..47110811, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44383181..44500108, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Neighboring gene ribosomal protein S21 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9420 Neighboring gene ST8SIA5 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr18:44374579-44375080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13281 Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13282 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:44447848-44449047 Neighboring gene uncharacterized LOC124904294 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:44479065-44479890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44490867-44491368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44491369-44491868 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:44496866-44497619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44499127-44499879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9423 Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44546997-44547496 Neighboring gene elongin A3 family member D, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44552405-44553168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44553169-44553932 Neighboring gene elongin A3 family member B, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia. Magalhaes J, et al. Mol Psychiatry, 2021 Oct. PMID 34234281, Free PMC Article
  2. Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis. Gui Z, et al. Ann Transplant, 2019 Oct 4. PMID 31582715, Free PMC Article
  3. Protein Inhibitor of Activated STAT2 Restricts HCV Replication by Modulating Viral Proteins Degradation. Guo J, et al. Viruses, 2017 Sep 30. PMID 28973998, Free PMC Article
  4. PIASxalpha differentially regulates the amplitudes of transcriptional responses following activation of the ERK and p38 MAPK pathways. Yang SH, et al. Mol Cell, 2006 May 19. PMID 16713578
  5. Molecular cloning and characterization of a novel splicing variant of PIASx. Zheng Y, et al. Acta Pharmacol Sin, 2004 Aug. PMID 15301740

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy.
    Title: Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy.
  2. Expression of PIAS Genes in Migraine Patients.
    Title: Expression of PIAS Genes in Migraine Patients.
  3. PIAS2-mediated blockade of IFN-beta signaling: a basis for sporadic Parkinson disease dementia.
    Title: PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.
  4. SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.
    Title: SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.
  5. PIAS genes as disease markers in bipolar disorder.
    Title: PIAS genes as disease markers in bipolar disorder.
  6. We are the first to reveal that mutations of rs644731 in the PIAS2 gene were significantly correlated with the progression of interstitial fibrosis and tubular atrophy in kidney transplant recipients.
    Title: Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis.
  7. the results presented demonstrate that in heat-stressed HeLa cells, p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of transactivation by Elk-1.
    Title: p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of Elk-1 activity in heat-stressed HeLa cells.
  8. PIAS1expression of PIAS1 gene was increased in patients with MS compared to healthy subjects; also, there was a significant correlation between the expression of PIAS1 and PIAS2 genes with disease severity of multiple sclerosis
    Title: The investigation of relevancy between PIAS1 and PIAS2 gene expression and disease severity of multiple sclerosis.
  9. results indicated that PIAS2-mediated SUMOylation constrained HCV replication
    Title: Protein Inhibitor of Activated STAT2 Restricts HCV Replication by Modulating Viral Proteins Degradation.
  10. the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype.
    Title: PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102682

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SUMO transferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation TAS
Traceable Author Statement
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 SUMO-protein ligase PIAS2
Names
DAB2-interacting protein
E3 SUMO-protein transferase PIAS2
androgen receptor-interacting protein 3
msx-interacting zinc finger protein
protein inhibitor of activated STAT X
zinc finger, MIZ-type containing 4
NP_001310975.1
NP_001310976.1
NP_001310977.1
NP_001310978.1
NP_001310980.1
NP_001310981.1
NP_001310982.1
NP_001310983.1
NP_001310984.1
NP_001310986.1
NP_001310987.1
NP_001310988.1
NP_001310989.1
NP_001340962.1
NP_001340963.1
NP_001340964.1
NP_001340965.1
NP_001340966.1
NP_001340967.1
NP_001340968.1
NP_004662.2
NP_775298.1
XP_006722636.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029865.2 RefSeqGene

    Range
    5026..119315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001324046.2 → NP_001310975.1  E3 SUMO-protein ligase PIAS2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 282
    PINIT; PINIT domain

  2. NM_001324047.2 → NP_001310976.1  E3 SUMO-protein ligase PIAS2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 287
    PINIT; PINIT domain

  3. NM_001324048.2 → NP_001310977.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 282
    PINIT; PINIT domain

  4. NM_001324049.2 → NP_001310978.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 282
    PINIT; PINIT domain

  5. NM_001324051.2 → NP_001310980.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 287
    PINIT; PINIT domain

  6. NM_001324052.2 → NP_001310981.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 287
    PINIT; PINIT domain

  7. NM_001324053.2 → NP_001310982.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 287
    PINIT; PINIT domain

  8. NM_001324054.2 → NP_001310983.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 287
    PINIT; PINIT domain

  9. NM_001324055.2 → NP_001310984.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138 → 282
    PINIT; PINIT domain
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

  10. NM_001324057.2 → NP_001310986.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138 → 282
    PINIT; PINIT domain
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

  11. NM_001324058.2 → NP_001310987.1  E3 SUMO-protein ligase PIAS2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373, BC111060
    UniProtKB/TrEMBL
    A0A087WUY7, Q2TA77
    Conserved Domains (3) summary
    smart00513
    Location:11 → 45
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:342 → 390
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:145 → 282
    PINIT; PINIT domain

  12. NM_001324059.2 → NP_001310988.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Related
    ENSP00000479025.1, ENST00000592212.5
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138 → 282
    PINIT; PINIT domain
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

  13. NM_001324060.2 → NP_001310989.1  E3 SUMO-protein ligase PIAS2 isoform NY

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform NY from PMID: 15301740.
    Source sequence(s)
    AC090241, AF361054
    UniProtKB/Swiss-Prot
    O75928
    Related
    ENST00000592011.5

  14. NM_001354033.2 → NP_001340962.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 287
    PINIT; PINIT domain

  15. NM_001354034.2 → NP_001340963.1  E3 SUMO-protein ligase PIAS2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:11 → 45
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:343 → 390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:147 → 296
    PINIT; PINIT domain

  16. NM_001354035.2 → NP_001340964.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 282
    PINIT; PINIT domain

  17. NM_001354036.2 → NP_001340965.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 282
    PINIT; PINIT domain

  18. NM_001354037.2 → NP_001340966.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138 → 282
    PINIT; PINIT domain
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

  19. NM_001354038.2 → NP_001340967.1  E3 SUMO-protein ligase PIAS2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 287
    PINIT; PINIT domain

  20. NM_001354039.2 → NP_001340968.1  E3 SUMO-protein ligase PIAS2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:334 → 381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:138 → 287
    PINIT; PINIT domain

  21. NM_004671.5 → NP_004662.2  E3 SUMO-protein ligase PIAS2 isoform beta

    See identical proteins and their annotated locations for NP_004662.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) encodes isoform (beta).
    Source sequence(s)
    AC090241, AF077954, AF086240, BG718291
    Consensus CDS
    CCDS32824.1
    UniProtKB/Swiss-Prot
    O75927, O75928, Q96BT5, Q96KE3
    Related
    ENSP00000465676.1, ENST00000585916.6
    Conserved Domains (3) summary
    smart00513
    Location:11 → 45
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:343 → 390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:147 → 296
    PINIT; PINIT domain

  22. NM_173206.4 → NP_775298.1  E3 SUMO-protein ligase PIAS2 isoform alpha

    See identical proteins and their annotated locations for NP_775298.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) utilizes an alternate 3' coding exon, compared to variant beta, resulting in a shorter isoform (alpha) that has a unique C-terminus compared to isoform beta.
    Source sequence(s)
    AC090241, BC015190, BG718291
    Consensus CDS
    CCDS32825.1
    UniProtKB/TrEMBL
    A0A087WUY7
    Related
    ENSP00000317163.6, ENST00000324794.11
    Conserved Domains (3) summary
    smart00513
    Location:11 → 45
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:343 → 390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:147 → 296
    PINIT; PINIT domain

RNA

  1. NR_136684.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373, AF086240, AK308143

  2. NR_136685.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373, AK294801

  3. NR_148699.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373

  4. NR_148700.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373

  5. NR_148701.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373

  6. NR_148702.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373

  7. NR_148703.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    46803218..46920145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722573.3 → XP_006722636.1  E3 SUMO-protein ligase PIAS2 isoform X1

    UniProtKB/TrEMBL
    A0A087WUY7
    Conserved Domains (3) summary
    smart00513
    Location:50 → 84
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:381 → 429
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:184 → 321
    PINIT; PINIT domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    46993864..47110811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75928.3 GenPept UniProtKB/Swiss-Prot:O75928

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