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SLC16A5 solute carrier family 16 member 5 [ Homo sapiens (human) ]

Gene ID: 9121, updated on 11-Apr-2024

Summary

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Official Symbol
SLC16A5provided by HGNC
Official Full Name
solute carrier family 16 member 5provided by HGNC
Primary source
HGNC:HGNC:10926
See related
Ensembl:ENSG00000170190 MIM:603879; AllianceGenome:HGNC:10926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT5; MCT6
Summary
This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Broad expression in lung (RPKM 9.8), duodenum (RPKM 9.3) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
17q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75087385..75110149)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75978846..76001616)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73083860..73102257)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73037362-73037932 Neighboring gene potassium channel tetramerization domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 3986 Neighboring gene RNA, 7SL, cytoplasmic 573, pseudogene Neighboring gene ATP synthase peripheral stalk subunit d Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12732 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73074528-73075727 Neighboring gene tripartite motif containing 80, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73089299-73089872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73089873-73090445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73100784-73101284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73101285-73101785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73110035-73110574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12735 Neighboring gene armadillo repeat containing 7 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:73120068-73121267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12736 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73126856-73127060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8956 Neighboring gene uncharacterized LOC107985034 Neighboring gene 5', 3'-nucleotidase, cytosolic Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73143638-73144837 Neighboring gene Jupiter microtubule associated homolog 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Solute carrier family 16 member 5 downregulation and its methylation might serve as a prognostic indicator of prostate cancer. Meng X, et al. IUBMB Life, 2021 Nov. PMID 34549875
  2. Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer. Drögemöller BI, et al. JAMA Oncol, 2017 Nov 1. PMID 28448657, Free PMC Article
  3. Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions. Sugito K, et al. Pediatr Blood Cancer, 2013 Mar. PMID 22911660
  4. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). Murakami Y, et al. Drug Metab Dispos, 2005 Dec. PMID 16174808
  5. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Price NT, et al. Biochem J, 1998 Jan 15. PMID 9425115, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Solute carrier family 16 member 5 downregulation and its methylation might serve as a prognostic indicator of prostate cancer.
    Title: Solute carrier family 16 member 5 downregulation and its methylation might serve as a prognostic indicator of prostate cancer.
  2. Identify a novel association between protein-coding variation in SLC16A5 and cisplatin-induced ototoxic effects in testicular cancer patients.
    Title: Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer.
  3. We demonstrated that SLC16A5 and ZNF206 displayed altered methylation patterns in the neuroblastoma genome
    Title: Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 6
Names
monocarboxylate transporter 5
solute carrier family 16 (monocarboxylate transporter), member 5
solute carrier family 16 (monocarboxylic acid transporters), member 5
solute carrier family 16, member 5 (monocarboxylic acid transporter 6)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271765.2 → NP_001258694.1  monocarboxylate transporter 6

    See identical proteins and their annotated locations for NP_001258694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK000416, AW452009
    Consensus CDS
    CCDS11713.1
    UniProtKB/Swiss-Prot
    B4E288, O15375
    UniProtKB/TrEMBL
    B3KS01
    Related
    ENSP00000463434.1, ENST00000580123.5
    Conserved Domains (1) summary
    TIGR00892
    Location:1 → 453
    2A0113; monocarboxylate transporter 1

  2. NM_001369668.1 → NP_001356597.1  monocarboxylate transporter 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC111186, BC033611, U59299
    Consensus CDS
    CCDS11713.1
    UniProtKB/Swiss-Prot
    B4E288, O15375
    UniProtKB/TrEMBL
    B3KS01
    Related
    ENSP00000390564.2, ENST00000450736.6
    Conserved Domains (1) summary
    TIGR00892
    Location:1 → 453
    2A0113; monocarboxylate transporter 1

  3. NM_004695.4 → NP_004686.1  monocarboxylate transporter 6

    See identical proteins and their annotated locations for NP_004686.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK000416, AW452009, BC009684, BC033611, BI820515
    Consensus CDS
    CCDS11713.1
    UniProtKB/Swiss-Prot
    B4E288, O15375
    UniProtKB/TrEMBL
    B3KS01
    Related
    ENSP00000330141.4, ENST00000329783.9
    Conserved Domains (1) summary
    TIGR00892
    Location:1 → 453
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    75087385..75110149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437035.1 → XP_047292991.1  monocarboxylate transporter 6 isoform X10

  2. XM_047437027.1 → XP_047292983.1  monocarboxylate transporter 6 isoform X4

  3. XM_047437028.1 → XP_047292984.1  monocarboxylate transporter 6 isoform X4

  4. XM_047437031.1 → XP_047292987.1  monocarboxylate transporter 6 isoform X4

  5. XM_047437026.1 → XP_047292982.1  monocarboxylate transporter 6 isoform X4

  6. XM_047437029.1 → XP_047292985.1  monocarboxylate transporter 6 isoform X4

  7. XM_047437024.1 → XP_047292980.1  monocarboxylate transporter 6 isoform X4

  8. XM_047437025.1 → XP_047292981.1  monocarboxylate transporter 6 isoform X4

  9. XM_047437033.1 → XP_047292989.1  monocarboxylate transporter 6 isoform X7

  10. XM_047437022.1 → XP_047292978.1  monocarboxylate transporter 6 isoform X2

  11. XM_047437030.1 → XP_047292986.1  monocarboxylate transporter 6 isoform X4

  12. XM_047437021.1 → XP_047292977.1  monocarboxylate transporter 6 isoform X1

  13. XM_047437023.1 → XP_047292979.1  monocarboxylate transporter 6 isoform X3

  14. XM_005257790.2 → XP_005257847.1  monocarboxylate transporter 6 isoform X6

    UniProtKB/TrEMBL
    B3KS01
    Related
    ENSP00000440212.2, ENST00000538213.6
    Conserved Domains (2) summary
    cd06174
    Location:54 → 452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:41 → 493
    2A0113; monocarboxylate transporter 1

  15. XM_011525462.2 → XP_011523764.1  monocarboxylate transporter 6 isoform X8

    Conserved Domains (2) summary
    cd06174
    Location:72 → 419
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:84 → 419
    MFS_1; Major Facilitator Superfamily

  16. XM_047437032.1 → XP_047292988.1  monocarboxylate transporter 6 isoform X5

  17. XM_047437034.1 → XP_047292990.1  monocarboxylate transporter 6 isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75978846..76001616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317756.1 → XP_054173731.1  monocarboxylate transporter 6 isoform X10

  2. XM_054317745.1 → XP_054173720.1  monocarboxylate transporter 6 isoform X4

  3. XM_054317747.1 → XP_054173722.1  monocarboxylate transporter 6 isoform X4

  4. XM_054317750.1 → XP_054173725.1  monocarboxylate transporter 6 isoform X4

  5. XM_054317743.1 → XP_054173718.1  monocarboxylate transporter 6 isoform X4

  6. XM_054317744.1 → XP_054173719.1  monocarboxylate transporter 6 isoform X4

  7. XM_054317746.1 → XP_054173721.1  monocarboxylate transporter 6 isoform X4

  8. XM_054317748.1 → XP_054173723.1  monocarboxylate transporter 6 isoform X4

  9. XM_054317753.1 → XP_054173728.1  monocarboxylate transporter 6 isoform X7

  10. XM_054317741.1 → XP_054173716.1  monocarboxylate transporter 6 isoform X2

  11. XM_054317749.1 → XP_054173724.1  monocarboxylate transporter 6 isoform X4

  12. XM_054317742.1 → XP_054173717.1  monocarboxylate transporter 6 isoform X3

  13. XM_054317740.1 → XP_054173715.1  monocarboxylate transporter 6 isoform X1

  14. XM_054317752.1 → XP_054173727.1  monocarboxylate transporter 6 isoform X6

  15. XM_054317754.1 → XP_054173729.1  monocarboxylate transporter 6 isoform X8

  16. XM_054317751.1 → XP_054173726.1  monocarboxylate transporter 6 isoform X5

  17. XM_054317755.1 → XP_054173730.1  monocarboxylate transporter 6 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15375.1 GenPept UniProtKB/Swiss-Prot:O15375

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