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DDX60L DExD/H-box 60 like [ Homo sapiens (human) ]

Gene ID: 91351, updated on 3-Apr-2024

Summary

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Official Symbol
DDX60Lprovided by HGNC
Official Full Name
DExD/H-box 60 likeprovided by HGNC
Primary source
HGNC:HGNC:26429
See related
Ensembl:ENSG00000181381 MIM:616725; AllianceGenome:HGNC:26429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in appendix (RPKM 7.8), bone marrow (RPKM 6.5) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
4q32.3
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (168356735..168480492, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (171715723..171840118, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (169277886..169401643, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene annexin A10 Neighboring gene uncharacterized LOC105377524 Neighboring gene DExD/H-box helicase 60 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22124 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76106 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76110 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76113 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76114 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22125 Neighboring gene uncharacterized LOC107986198 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:169408038-169409237 Neighboring gene uncharacterized LOC124900807 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76181 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76192 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene basic transcription factor 3 like 4 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and functional analysis of novel oncogene DDX60L in pancreatic ductal adenocarcinoma. Wu H, et al. BMC Genomics, 2021 Nov 18. PMID 34789165, Free PMC Article
  2. DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture. Grünvogel O, et al. J Virol, 2015 Oct. PMID 26269178, Free PMC Article
  3. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. Chalasani N, et al. Gastroenterology, 2010 Nov. PMID 20708005, Free PMC Article
  4. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. Zhu X, et al. FASEB J, 2016 Feb. PMID 26472337
  5. Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. Lum KK, et al. Cell Syst, 2018 Dec 26. PMID 30471916, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and functional analysis of novel oncogene DDX60L in pancreatic ductal adenocarcinoma.
    Title: Identification and functional analysis of novel oncogene DDX60L in pancreatic ductal adenocarcinoma.
  2. DDX60L is an interferon-gamma stimulated gene product restricting Hepatitis C virus replication in cell culture.
    Title: DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like (DDX60L) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13468, FLJ31033, FLJ39050, DKFZp781D1175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX60-like
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
DEAD box protein 60-like
DEAD-box helicase 60 like
putative ATP-dependent RNA helicase DDX60
NP_001012985.2
NP_001278439.1
NP_001332856.1
NP_001364998.1
NP_001364999.1
NP_001365000.1
NP_001365001.1
XP_005263398.2
XP_005263400.2
XP_006714471.1
XP_011530704.1
XP_011530705.1
XP_011530707.1
XP_011530708.1
XP_011530711.1
XP_016864318.1
XP_016864319.1
XP_047272351.1
XP_047272352.1
XP_047272353.1
XP_047272355.1
XP_047272356.1
XP_047272357.1
XP_047272358.1
XP_047272359.1
XP_047272360.1
XP_054207198.1
XP_054207199.1
XP_054207200.1
XP_054207201.1
XP_054207202.1
XP_054207203.1
XP_054207204.1
XP_054207205.1
XP_054207206.1
XP_054207207.1
XP_054207208.1
XP_054207209.1
XP_054207210.1
XP_054207211.1
XP_054207212.1
XP_054207213.1
XP_054207214.1
XP_054207215.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051576.1 RefSeqGene

    Range
    5023..128780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012967.3 → NP_001012985.2  probable ATP-dependent RNA helicase DDX60-like isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC079926, AC093888, AK055595, AL832950, CR933601, DA553350, EB710202
    Consensus CDS
    CCDS47161.1
    UniProtKB/Swiss-Prot
    A0A804HKC9, Q5H9U9, Q96ND6
    UniProtKB/TrEMBL
    A0A0K1H1B1
    Related
    ENSP00000507872.1, ENST00000682922.1
    Conserved Domains (2) summary
    smart00490
    Location:1238 → 1314
    HELICc; helicase superfamily c-terminal domain
    pfam00270
    Location:748 → 902
    DEAD; DEAD/DEAH box helicase

  2. NM_001291510.2 → NP_001278439.1  probable ATP-dependent RNA helicase DDX60-like isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC079926, AC093888, AK092461, CR933601, DA553350
    UniProtKB/Swiss-Prot
    Q5H9U9
    Related
    ENSP00000422202.1, ENST00000505890.5
    Conserved Domains (2) summary
    smart00490
    Location:1239 → 1308
    HELICc; helicase superfamily c-terminal domain
    pfam00270
    Location:748 → 902
    DEAD; DEAD/DEAH box helicase

  3. NM_001345927.2 → NP_001332856.1  probable ATP-dependent RNA helicase DDX60-like isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC079926, AC093888, KF457833
    UniProtKB/TrEMBL
    A0A0K1H1B1
    Conserved Domains (2) summary
    COG4581
    Location:742 → 1358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743 → 926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  4. NM_001378069.1 → NP_001364998.1  probable ATP-dependent RNA helicase DDX60-like isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC079926
    UniProtKB/TrEMBL
    D6RB62

  5. NM_001378070.1 → NP_001364999.1  probable ATP-dependent RNA helicase DDX60-like isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC079926
    UniProtKB/TrEMBL
    D6RB62
    Related
    ENSP00000424396.1, ENST00000514748.5

  6. NM_001378071.1 → NP_001365000.1  probable ATP-dependent RNA helicase DDX60-like isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC079926
    UniProtKB/TrEMBL
    D6RB62

  7. NM_001378072.1 → NP_001365001.1  probable ATP-dependent RNA helicase DDX60-like isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC079926, AC093888, KF457833
    UniProtKB/TrEMBL
    A0A0K1H1B1
    Conserved Domains (2) summary
    COG4581
    Location:742 → 1358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743 → 926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    168356735..168480492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416399.1 → XP_047272355.1  probable ATP-dependent RNA helicase DDX60-like isoform X2

    UniProtKB/Swiss-Prot
    A0A804HKC9, Q5H9U9, Q96ND6

  2. XM_005263341.5 → XP_005263398.2  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_005263398.2

    UniProtKB/TrEMBL
    A0A0K1H1B1
    Conserved Domains (2) summary
    COG4581
    Location:742 → 1358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743 → 926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  3. XM_011532403.3 → XP_011530705.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_011530705.1

    UniProtKB/TrEMBL
    A0A0K1H1B1
    Conserved Domains (2) summary
    COG4581
    Location:742 → 1358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743 → 926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  4. XM_047416395.1 → XP_047272351.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  5. XM_011532405.2 → XP_011530707.1  probable ATP-dependent RNA helicase DDX60-like isoform X4

    UniProtKB/TrEMBL
    A0A0K1H1B1
    Conserved Domains (2) summary
    smart00490
    Location:1206 → 1282
    HELICc; helicase superfamily c-terminal domain
    cl21455
    Location:748 → 812
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. XM_047416401.1 → XP_047272357.1  probable ATP-dependent RNA helicase DDX60-like isoform X8

  7. XM_047416400.1 → XP_047272356.1  probable ATP-dependent RNA helicase DDX60-like isoform X7

  8. XM_017008830.2 → XP_016864319.1  probable ATP-dependent RNA helicase DDX60-like isoform X6

    UniProtKB/TrEMBL
    A0A0K1H1B1

  9. XM_011532406.2 → XP_011530708.1  probable ATP-dependent RNA helicase DDX60-like isoform X5

    UniProtKB/TrEMBL
    A0A0K1H1B1
    Conserved Domains (2) summary
    smart00490
    Location:1239 → 1315
    HELICc; helicase superfamily c-terminal domain
    pfam00270
    Location:748 → 902
    DEAD; DEAD/DEAH box helicase

  10. XM_006714408.3 → XP_006714471.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_006714471.1

    UniProtKB/TrEMBL
    A0A0K1H1B1
    Conserved Domains (2) summary
    COG4581
    Location:742 → 1358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743 → 926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  11. XM_011532402.3 → XP_011530704.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_011530704.1

    UniProtKB/TrEMBL
    A0A0K1H1B1
    Conserved Domains (2) summary
    COG4581
    Location:742 → 1358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743 → 926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  12. XM_047416397.1 → XP_047272353.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  13. XM_047416396.1 → XP_047272352.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  14. XM_017008829.2 → XP_016864318.1  probable ATP-dependent RNA helicase DDX60-like isoform X3

    UniProtKB/TrEMBL
    A0A0K1H1B1
    Conserved Domains (2) summary
    smart00490
    Location:1207 → 1283
    HELICc; helicase superfamily c-terminal domain
    cl21455
    Location:748 → 812
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  15. XM_005263343.3 → XP_005263400.2  probable ATP-dependent RNA helicase DDX60-like isoform X1

    See identical proteins and their annotated locations for XP_005263400.2

    UniProtKB/TrEMBL
    A0A0K1H1B1
    Conserved Domains (2) summary
    COG4581
    Location:742 → 1358
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cl28899
    Location:743 → 926
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  16. XM_011532409.4 → XP_011530711.1  probable ATP-dependent RNA helicase DDX60-like isoform X10

    See identical proteins and their annotated locations for XP_011530711.1

    Conserved Domains (2) summary
    smart00490
    Location:625 → 701
    HELICc; helicase superfamily c-terminal domain
    pfam00270
    Location:134 → 288
    DEAD; DEAD/DEAH box helicase

  17. XM_047416403.1 → XP_047272359.1  probable ATP-dependent RNA helicase DDX60-like isoform X10

  18. XM_047416402.1 → XP_047272358.1  probable ATP-dependent RNA helicase DDX60-like isoform X9

  19. XM_047416404.1 → XP_047272360.1  probable ATP-dependent RNA helicase DDX60-like isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    171715723..171840118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351230.1 → XP_054207205.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  2. XM_054351231.1 → XP_054207206.1  probable ATP-dependent RNA helicase DDX60-like isoform X2

  3. XM_054351224.1 → XP_054207199.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  4. XM_054351227.1 → XP_054207202.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  5. XM_054351232.1 → XP_054207207.1  probable ATP-dependent RNA helicase DDX60-like isoform X3

  6. XM_054351229.1 → XP_054207204.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  7. XM_054351233.1 → XP_054207208.1  probable ATP-dependent RNA helicase DDX60-like isoform X4

  8. XM_054351236.1 → XP_054207211.1  probable ATP-dependent RNA helicase DDX60-like isoform X7

  9. XM_054351235.1 → XP_054207210.1  probable ATP-dependent RNA helicase DDX60-like isoform X6

  10. XM_054351234.1 → XP_054207209.1  probable ATP-dependent RNA helicase DDX60-like isoform X5

  11. XM_054351223.1 → XP_054207198.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  12. XM_054351225.1 → XP_054207200.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  13. XM_054351228.1 → XP_054207203.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  14. XM_054351226.1 → XP_054207201.1  probable ATP-dependent RNA helicase DDX60-like isoform X1

  15. XM_054351239.1 → XP_054207214.1  probable ATP-dependent RNA helicase DDX60-like isoform X10

  16. XM_054351238.1 → XP_054207213.1  probable ATP-dependent RNA helicase DDX60-like isoform X10

  17. XM_054351237.1 → XP_054207212.1  probable ATP-dependent RNA helicase DDX60-like isoform X9

  18. XM_054351240.1 → XP_054207215.1  probable ATP-dependent RNA helicase DDX60-like isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5H9U9.3 GenPept UniProtKB/Swiss-Prot:Q5H9U9

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