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UBXN11 UBX domain protein 11 [ Homo sapiens (human) ]

Gene ID: 91544, updated on 5-Mar-2024

Summary

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Official Symbol
UBXN11provided by HGNC
Official Full Name
UBX domain protein 11provided by HGNC
Primary source
HGNC:HGNC:30600
See related
Ensembl:ENSG00000158062 MIM:609151; AllianceGenome:HGNC:30600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOC; SOCI; COA-1; UBXD5; PP2243
Summary
This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 18.9), spleen (RPKM 17.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1p36.11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26282282..26318355, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26119766..26155807, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26608773..26644846, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene centrosomal protein 85 Neighboring gene mitochondrial ribosomal protein S6 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:26602348-26603547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26606098-26606985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26606986-26607872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26610368-26610958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 487 Neighboring gene SH3 domain binding glutamate rich protein like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26616244-26617056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26617057-26617870 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:26629035-26630234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 494 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26644239-26644431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26645229-26646214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26648235-26648736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26655253-26655760 Neighboring gene crystallin beta-gamma domain containing 2 Neighboring gene CD52 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 476 Neighboring gene ribosomal protein L34 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26672818-26673571 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:26675860-26676706 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26677922-26678120 Neighboring gene Sharpr-MPRA regulatory region 4973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26688162-26688861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26690731-26691232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26691233-26691732 Neighboring gene zinc finger protein 683

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Induction of both CD8+ and CD4+ T-cell-mediated responses in colorectal cancer patients by colon antigen-1. Maccalli C, et al. Clin Cancer Res, 2008 Nov 15. PMID 18974390
  2. Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation. Tateiwa K, et al. Biochem Biophys Res Commun, 2005 Nov 18. PMID 16202387
  3. Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes. Maccalli C, et al. Cancer Res, 2003 Oct 15. PMID 14583468, Free PMC Article
  4. Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. Hu Y, et al. PLoS Pathog, 2017 Feb. PMID 28152074, Free PMC Article
  5. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. Katoh H, et al. Mol Cell Biol, 2002 May. PMID 11940653, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both CD4+ and CD8+ T-cell responses against COA-1 can occur in colorectal cancer patients with metastatic disease
    Title: Induction of both CD8+ and CD4+ T-cell-mediated responses in colorectal cancer patients by colon antigen-1.
  2. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers
    Title: Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.
  3. The rat homolog of UBXD5 promotes RhoA activation through G12/13 heterotrimeric G proteins
    Title: Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • DKFZp686F04228

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
UBX domain-containing protein 11
Names
UBX domain-containing protein 5
colorectal tumor-associated antigen COA-1
colorectal tumor-associated antigen-1
socius

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028986.1 RefSeqGene

    Range
    16630..40984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001077262.2 → NP_001070730.1  UBX domain-containing protein 11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL451139
    Consensus CDS
    CCDS41287.1
    UniProtKB/Swiss-Prot
    Q5T124
    Related
    ENSP00000324721.7, ENST00000314675.11
    Conserved Domains (2) summary
    pfam08059
    Location:115 → 185
    SEP; SEP domain
    cl00155
    Location:275 → 343
    UBQ; Ubiquitin-like proteins

  2. NM_001389556.1 → NP_001376485.1  UBX domain-containing protein 11 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL451139
    Consensus CDS
    CCDS41288.1
    UniProtKB/Swiss-Prot
    D3DPK6, Q5T117, Q5T120, Q5T124, Q5T125, Q5T126, Q5T129, Q5T131, Q5T133, Q63HM6, Q71RB3, Q8IY27, Q8N1L6, Q8N9M4, Q8NA18, Q8NFE3, Q8NFE4, Q8NFE6
    Related
    ENSP00000363339.1, ENST00000374222.6
    Conserved Domains (3) summary
    PRK13405
    Location:119 → 256
    bchH; magnesium chelatase subunit H; Provisional
    cd17077
    Location:395 → 464
    UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
    pfam08059
    Location:235 → 306
    SEP; SEP domain

  3. NM_001389559.1 → NP_001376488.1  UBX domain-containing protein 11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL451139
    Consensus CDS
    CCDS41286.1
    Related
    ENSP00000349601.4, ENST00000357089.8
    Conserved Domains (3) summary
    PRK13405
    Location:86 → 223
    bchH; magnesium chelatase subunit H; Provisional
    cd17077
    Location:362 → 431
    UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
    pfam08059
    Location:202 → 273
    SEP; SEP domain

  4. NM_145345.3 → NP_663320.2  UBX domain-containing protein 11 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL451139
    Consensus CDS
    CCDS41286.1
    UniProtKB/Swiss-Prot
    Q5T124
    Related
    ENSP00000363334.2, ENST00000374217.7
    Conserved Domains (3) summary
    PRK13405
    Location:86 → 223
    bchH; magnesium chelatase subunit H; Provisional
    cd17077
    Location:362 → 431
    UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
    pfam08059
    Location:202 → 273
    SEP; SEP domain

  5. NM_183008.3 → NP_892120.2  UBX domain-containing protein 11 isoform 2

    See identical proteins and their annotated locations for NP_892120.2

    Status: REVIEWED

    Source sequence(s)
    AL451139
    Consensus CDS
    CCDS41288.1
    UniProtKB/Swiss-Prot
    D3DPK6, Q5T117, Q5T120, Q5T124, Q5T125, Q5T126, Q5T129, Q5T131, Q5T133, Q63HM6, Q71RB3, Q8IY27, Q8N1L6, Q8N9M4, Q8NA18, Q8NFE3, Q8NFE4, Q8NFE6
    Related
    ENSP00000363338.3, ENST00000374221.7
    Conserved Domains (3) summary
    PRK13405
    Location:119 → 256
    bchH; magnesium chelatase subunit H; Provisional
    cd17077
    Location:395 → 464
    UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
    pfam08059
    Location:235 → 306
    SEP; SEP domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26282282..26318355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    26119766..26155807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T124.2 GenPept UniProtKB/Swiss-Prot:Q5T124

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