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MAP3K13 mitogen-activated protein kinase kinase kinase 13 [ Homo sapiens (human) ]

Gene ID: 9175, updated on 5-Mar-2024

Summary

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Official Symbol
MAP3K13provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 13provided by HGNC
Primary source
HGNC:HGNC:6852
See related
Ensembl:ENSG00000073803 MIM:604915; AllianceGenome:HGNC:6852
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LZK; MLK; MEKK13
Summary
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

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See MAP3K13 in Genome Data Viewer
Location:
3q27.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (185282961..185489094)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (188098494..188304852)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185000749..185206882)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Neighboring gene uncharacterized LOC124900548 Neighboring gene microRNA 5588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14973 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:184999880-185001079 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20923 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein L4 pseudogene 4 Neighboring gene MPRA-validated peak4968 silencer Neighboring gene uncharacterized LOC124906312 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:185190839-185192038 Neighboring gene uncharacterized LOC101929018 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:185197816-185199015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14975 Neighboring gene uncharacterized LOC105374254 Neighboring gene transmembrane protein 41A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration. Liu Z, et al. Bioengineered, 2022 Mar. PMID 35311629, Free PMC Article
  2. Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene. Ikeda A, et al. J Biochem Mol Biol Biophys, 2002 Apr. PMID 12186766
  3. Identification and characterization of functional domains in a mixed lineage kinase LZK. Ikeda A, et al. FEBS Lett, 2001 Jan 19. PMID 11163770
  4. microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13. Han H, et al. Oncotarget, 2016 Mar 29. PMID 26918941, Free PMC Article
  5. Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. Sakuma H, et al. J Biol Chem, 1997 Nov 7. PMID 9353328

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration.
    Title: Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration.
  2. The MAP3K13-TRIM25-FBXW7alpha axis affects c-Myc protein stability and tumor development.
    Title: The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development.
  3. Data indicate that miR-206's effect on Myc was mediated through MAP3K13.
    Title: microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13.
  4. LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury.
    Title: Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Chromosomal localization studies involving FISH mapping demonstrated that the human LZK gene is located at 3q27.
    Title: Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC133196

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables IkappaB kinase complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of branching morphogenesis of a nerve ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 13
Names
leucine zipper-bearing kinase
mixed lineage kinase
NP_001229243.1
NP_001229246.1
NP_004712.1
XP_011511612.1
XP_016862945.1
XP_016862946.1
XP_047305149.1
XP_054204332.1
XP_054204333.1
XP_054204334.1
XP_054204335.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242314.2 → NP_001229243.1  mitogen-activated protein kinase kinase kinase 13 isoform 1

    See identical proteins and their annotated locations for NP_001229243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC099661, AK312714, BQ432918
    Consensus CDS
    CCDS3270.1
    UniProtKB/Swiss-Prot
    B2R6U2, B4DLE3, B4DMV2, B4DZJ4, D3DNU1, O43283, Q05BY6, Q15450, Q2NKN3
    Related
    ENSP00000399910.1, ENST00000424227.5
    Conserved Domains (2) summary
    smart00221
    Location:168 → 402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174 → 410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  2. NM_001242317.2 → NP_001229246.1  mitogen-activated protein kinase kinase kinase 13 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC099661, AK297646
    Consensus CDS
    CCDS56298.1
    UniProtKB/Swiss-Prot
    O43283
    Related
    ENSP00000411483.1, ENST00000446828.5
    Conserved Domains (1) summary
    cl21453
    Location:13 → 203
    PKc_like; Protein Kinases, catalytic domain

  3. NM_004721.5 → NP_004712.1  mitogen-activated protein kinase kinase kinase 13 isoform 1

    See identical proteins and their annotated locations for NP_004712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB001872, AC099661, AC132516
    Consensus CDS
    CCDS3270.1
    UniProtKB/Swiss-Prot
    B2R6U2, B4DLE3, B4DMV2, B4DZJ4, D3DNU1, O43283, Q05BY6, Q15450, Q2NKN3
    Related
    ENSP00000265026.3, ENST00000265026.8
    Conserved Domains (2) summary
    smart00221
    Location:168 → 402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174 → 410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RNA

  1. NR_038322.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks eleven exons and contains an alternate 3' exon, compared to variant 3. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 3.
    Source sequence(s)
    AI690808, BC015996, BC036593, BQ432918
    Related
    ENST00000448876.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    185282961..185489094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449193.1 → XP_047305149.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/Swiss-Prot
    B2R6U2, B4DLE3, B4DMV2, B4DZJ4, D3DNU1, O43283, Q05BY6, Q15450, Q2NKN3

  2. XM_017007456.2 → XP_016862945.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/Swiss-Prot
    B2R6U2, B4DLE3, B4DMV2, B4DZJ4, D3DNU1, O43283, Q05BY6, Q15450, Q2NKN3
    Conserved Domains (2) summary
    smart00221
    Location:168 → 402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174 → 410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  3. XM_011513310.3 → XP_011511612.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    See identical proteins and their annotated locations for XP_011511612.1

    UniProtKB/Swiss-Prot
    B2R6U2, B4DLE3, B4DMV2, B4DZJ4, D3DNU1, O43283, Q05BY6, Q15450, Q2NKN3
    Conserved Domains (2) summary
    smart00221
    Location:168 → 402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174 → 410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

  4. XM_017007457.2 → XP_016862946.1  mitogen-activated protein kinase kinase kinase 13 isoform X2

    Related
    ENSP00000409325.1, ENST00000443863.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    188098494..188304852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348357.1 → XP_054204332.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/Swiss-Prot
    B2R6U2, B4DLE3, B4DMV2, B4DZJ4, D3DNU1, O43283, Q05BY6, Q15450, Q2NKN3

  2. XM_054348358.1 → XP_054204333.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/Swiss-Prot
    B2R6U2, B4DLE3, B4DMV2, B4DZJ4, D3DNU1, O43283, Q05BY6, Q15450, Q2NKN3

  3. XM_054348359.1 → XP_054204334.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/Swiss-Prot
    B2R6U2, B4DLE3, B4DMV2, B4DZJ4, D3DNU1, O43283, Q05BY6, Q15450, Q2NKN3

  4. XM_054348360.1 → XP_054204335.1  mitogen-activated protein kinase kinase kinase 13 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43283.1 GenPept UniProtKB/Swiss-Prot:O43283

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