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CD8B CD8 subunit beta [ Homo sapiens (human) ]

Gene ID: 926, updated on 11-Apr-2024

Summary

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Official Symbol
CD8Bprovided by HGNC
Official Full Name
CD8 subunit betaprovided by HGNC
Primary source
HGNC:HGNC:1707
See related
Ensembl:ENSG00000172116 MIM:186730; AllianceGenome:HGNC:1707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LY3; P37; LEU2; LYT3; Ly-3; CD8B1; CD8beta
Summary
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
Expression
Broad expression in lymph node (RPKM 4.6), small intestine (RPKM 2.3) and 14 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
2p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (86815369..86861886, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (86817280..86863804, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (87042492..87089009, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF103-CHMP3 readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr2:86947334-86947492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86952106-86952606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86952607-86953107 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16165 Neighboring gene CD8A intronic regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:87016737-87017571 Neighboring gene uncharacterized LOC105374846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11721 Neighboring gene MPRA-validated peak3783 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87066785-87067341 Neighboring gene CD8 subunit alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87083199-87083700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87083701-87084200 Neighboring gene ANAPC1 pseudogene 1 Neighboring gene RANBP2 like and GRIP domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 5 Neighboring gene WBP1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Thakral D, et al. J Immunol, 2008 Jun 1. PMID 18490743
  2. A second chain of human CD8 is expressed on peripheral blood lymphocytes. Shiue L, et al. J Exp Med, 1988 Dec 1. PMID 3264320, Free PMC Article
  3. CD8B, the human equivalent of the mouse Ly-3 gene is localized on chromosome 2. Spurr NK, et al. Immunogenetics, 1988. PMID 3257101
  4. The human Lyt-3 molecule requires CD8 for cell surface expression. DiSanto JP, et al. EMBO J, 1988 Nov. PMID 3145196, Free PMC Article
  5. A human homolog of the mouse CD8 molecule, Lyt-3: genomic sequence and expression. Johnson P. Immunogenetics, 1987. PMID 3114136

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
    Title: Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology.
  2. CD45RA, CD8beta, and IFNgamma Are Potential Immune Biomarkers of Human Cognitive Function.
    Title: CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function.
  3. results suggest that mycoplasma induces a resistance to multiple drugs in hepatocarcinoma cells which required the interaction of P37 and Annexin A2. The pathway downstream this interaction needs to be explored
    Title: Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2.
  4. Endometrioid endometrial carcinomas are capable of down-regulating CD8 expression by cytotoxic T lymphocytes.
    Title: CD8 down-regulation on cytotoxic T lymphocytes of patients with endometrioid endometrial carcinomas.
  5. CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.
    Title: cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.
  6. transcription factor cAMP-responsive element modulator alpha (CREMalpha), which is expressed at increased levels in T cells from systemic lupus erythematosus patients, contributes to transcriptional silencing of CD8A and CD8B.
    Title: cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.
  7. Nef-mediated down-modulation of CD8alphabeta is a fundamental property of primate lentiviruses.
    Title: Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.
  8. [review] Coreceptor CD8alphabeta contributes to the antigen-recognition process by binding to a largely invariant region of the MHCI molecule and by promoting intracellular signaling.
    Title: The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. Data show that CD8+LAP+ cells produce IFN-gamma, and these cells suppress EAE that is dependent on both TGF-beta and IFN-gamma.
    Title: Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
Nef nef HIV-1 Nef downregulates surface expression of the beta-chain of the CD8 receptor by accelerated endocytosis; amino acid positions 57 to 58 and 174 to 175 in Nef are involved in the down modulation PubMed
nef HIV-1 Nef interaction with AP-1gamma is required for CD28 and CD8beta downregulation PubMed
nef Downregulation of CD8beta by HIV-1 Nef requires an intact AP-2 complex PubMed
nef Co-localization of HIV-1 Nef and CD8beta is revealed by staining assays in 293T cells expressing both proteins PubMed
Pol gag-pol HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC class I protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables coreceptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in T cell activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adaptive immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of T cell receptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane TAS
Traceable Author Statement
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
T-cell surface glycoprotein CD8 beta chain
Names
CD8 antigen, beta polypeptide 1 (p37)
CD8b molecule
Ly-3 homolog
T lymphocyte surface glycoprotein beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178100.2 → NP_001171571.1  T-cell surface glycoprotein CD8 beta chain isoform 6 precursor

    See identical proteins and their annotated locations for NP_001171571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two exons in the 3' coding region, which results in a frameshift, compared to variant 2. The resulting protein (isoform 6) is shorter and has a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AW296309, BC100912, DC405359, X13445
    Consensus CDS
    CCDS54376.1
    UniProtKB/TrEMBL
    Q9UQ56
    Related
    ENSP00000377358.2, ENST00000393761.6
    Conserved Domains (2) summary
    cd07700
    Location:29 → 134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
    smart00410
    Location:26 → 134
    IG_like; Immunoglobulin like

  2. NM_004931.5 → NP_004922.1  T-cell surface glycoprotein CD8 beta chain isoform 5 precursor

    See identical proteins and their annotated locations for NP_004922.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as M-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AC111200, BC100912, BP392114, DB223179, DC405359, X13444
    Consensus CDS
    CCDS1997.1
    UniProtKB/Swiss-Prot
    P10966, P14860, P14861, Q15980, Q496E0, Q496E1, Q496E2, Q9UDB4, Q9UDB5, Q9UDB6, Q9UDB7, Q9UDB8, Q9UDB9, Q9UDC0, Q9UQ55
    UniProtKB/TrEMBL
    E9PD41
    Related
    ENSP00000375070.6, ENST00000390655.12
    Conserved Domains (2) summary
    cd07700
    Location:29 → 134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
    smart00410
    Location:26 → 134
    IG_like; Immunoglobulin like

  3. NM_172101.5 → NP_742099.1  T-cell surface glycoprotein CD8 beta chain isoform 3 precursor

    See identical proteins and their annotated locations for NP_742099.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as M-3, includes an alternate exon in the 3' coding region, which results in a frameshift compared to variant 2. The resulting membrane associated protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AW296309, BC100912, DC405359, X13445
    Consensus CDS
    CCDS42708.1
    UniProtKB/TrEMBL
    B4E0F8, E7EPH5
    Related
    ENSP00000377356.2, ENST00000393759.6
    Conserved Domains (2) summary
    cd07700
    Location:29 → 134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
    smart00410
    Location:26 → 134
    IG_like; Immunoglobulin like

  4. NM_172102.5 → NP_742100.1  T-cell surface glycoprotein CD8 beta chain isoform 4 precursor

    See identical proteins and their annotated locations for NP_742100.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as S-1, lacks an in-frame exon in the coding region, compared to variant 2. The resulting secreted protein (isoform 4) is shorter than isoform 2.
    Source sequence(s)
    AW296309, BC100912, DC405359, X13446
    Consensus CDS
    CCDS1994.1
    UniProtKB/TrEMBL
    B4E0F8, E7EPH5
    Related
    ENSP00000340592.3, ENST00000349455.7
    Conserved Domains (2) summary
    cd07700
    Location:29 → 134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
    smart00410
    Location:26 → 134
    IG_like; Immunoglobulin like

  5. NM_172213.5 → NP_757362.1  T-cell surface glycoprotein CD8 beta chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_757362.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AW296309, BC100912, BC100913, DC405359
    Consensus CDS
    CCDS1995.1
    UniProtKB/TrEMBL
    B4E0F8, E7EPH5
    Related
    ENSP00000331172.2, ENST00000331469.6
    Conserved Domains (1) summary
    cd07700
    Location:29 → 134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    86815369..86861886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533164.3 → XP_011531466.1  T-cell surface glycoprotein CD8 beta chain isoform X1

    See identical proteins and their annotated locations for XP_011531466.1

    UniProtKB/TrEMBL
    B4E0F8, E7EPH5, E9PD41, Q53QL8
    Conserved Domains (2) summary
    cd07700
    Location:29 → 134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
    smart00410
    Location:26 → 134
    IG_like; Immunoglobulin like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    86817280..86863804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344557.1 → XP_054200532.1  T-cell surface glycoprotein CD8 beta chain isoform X1

    UniProtKB/TrEMBL
    Q53QL8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172099.2: Suppressed sequence

    Description
    NM_172099.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

  2. NM_172100.1: Suppressed sequence

    Description
    NM_172100.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10966.1 GenPept UniProtKB/Swiss-Prot:P10966

Gene LinkOut

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