TAAR2 trace amine associated receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAAR2provided by HGNC
Official Full Name: trace amine associated receptor 2provided by HGNC
Primary source: HGNC:HGNC:4514
See related: Ensembl:ENSG00000146378 MIM:604849; AllianceGenome:HGNC:4514
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPR58; taR-2
Summary: Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 6q23.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (132617150..132624275, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (133812108..133819243, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (132938289..132945414, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

biogenic amines potently regulate blood cell functions via TAAR1 and TAAR2 and open the perspective of their specific pharmacological modulation.
Title: Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2.
Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines.
Title: A second class of chemosensory receptors in the olfactory epithelium.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables trace-amine receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trace amine-associated receptor 2

Names: G protein-coupled receptor 58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033080.1 → NP_001028252.1 trace amine-associated receptor 2 isoform 1

See identical proteins and their annotated locations for NP_001028252.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AY703480

Consensus CDS

CCDS34541.1

UniProtKB/Swiss-Prot

Q5QD02, Q6NWS1, Q6NWS2, Q6NWS3, Q9P1P5

Related

ENSP00000356908.1, ENST00000367931.1

Conserved Domains (2) summary

pfam00001
Location:60 → 315

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:53 → 180

7tm_4; Olfactory receptor
NM_014626.3 → NP_055441.2 trace amine-associated receptor 2 isoform 2

See identical proteins and their annotated locations for NP_055441.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks part of the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AY702304, DN693314

Consensus CDS

CCDS5157.1

UniProtKB/Swiss-Prot

Q9P1P5

Related

ENSP00000275191.2, ENST00000275191.2

Conserved Domains (2) summary

pfam00001
Location:15 → 270

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:8 → 135

7tm_4; Olfactory receptor