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GTF3C5 general transcription factor IIIC subunit 5 [ Homo sapiens (human) ]

Gene ID: 9328, updated on 3-Apr-2024

Summary

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Official Symbol
GTF3C5provided by HGNC
Official Full Name
general transcription factor IIIC subunit 5provided by HGNC
Primary source
HGNC:HGNC:4668
See related
Ensembl:ENSG00000148308 MIM:604890; AllianceGenome:HGNC:4668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIIC63; TFiiiC2-63; TFIIICepsilon
Summary
Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase III. Predicted to act upstream of or within skeletal muscle cell differentiation. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 17.0), testis (RPKM 11.6) and 25 other tissues See more
Orthologs
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Genomic context

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See GTF3C5 in Genome Data Viewer
Location:
9q34.13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (133030708..133058503)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (145244842..145272659)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135906384..135933890)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:135895195-135895887 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 Neighboring gene small nucleolar RNA, C/D box 141A Neighboring gene uncharacterized LOC105376306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:135906049-135906700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20441 Neighboring gene microRNA 6877 Neighboring gene uncharacterized LOC124902325 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:135935579-135936330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:135936331-135937083 Neighboring gene carboxyl ester lipase Neighboring gene carboxyl ester lipase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates. Mertens C, et al. Mol Cell Biol, 2008 Sep. PMID 18644873, Free PMC Article
  2. Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors. Sinn E, et al. Genes Dev, 1995 Mar 15. PMID 7729686
  3. The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. Böhm R, et al. Mol Cell, 2021 Jun 3. PMID 33852892
  4. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. Hsieh YJ, et al. Mol Cell Biol, 1999 Jul. PMID 10373544, Free PMC Article
  5. The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. Hsieh YJ, et al. Mol Cell Biol, 1999 Nov. PMID 10523658, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20857

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IC
Inferred by Curator
more info
 PubMed 
enables RNA polymerase III general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5S class rRNA transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
involved_in transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
involved_in transcription initiation at RNA polymerase III promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
general transcription factor 3C polypeptide 5
Names
TF3C-epsilon
TFIIIC 63 kDa subunit
general transcription factor IIIC, polypeptide 5, 63kDa
transcription factor IIIC 63 kDa subunit
transcription factor IIIC subunit epsilon
transcription factor IIIC, 63 kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122823.2 → NP_001116295.1  general transcription factor 3C polypeptide 5 isoform 1

    See identical proteins and their annotated locations for NP_001116295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ420443, DB194811
    Consensus CDS
    CCDS48050.1
    UniProtKB/TrEMBL
    Q5T7U1
    Related
    ENSP00000361180.5, ENST00000372108.9
    Conserved Domains (1) summary
    pfam09734
    Location:24 → 322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

  2. NM_001286709.2 → NP_001273638.1  general transcription factor 3C polypeptide 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' region, which results in translation initiation from an alternate start codon, and it lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL162417, BC017337, BQ673969, DB194811
    Consensus CDS
    CCDS75927.1
    UniProtKB/TrEMBL
    H7BY84
    Related
    ENSP00000361171.7, ENST00000372099.10
    Conserved Domains (1) summary
    pfam09734
    Location:25 → 148
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

  3. NM_012087.4 → NP_036219.2  general transcription factor 3C polypeptide 5 isoform 2

    See identical proteins and their annotated locations for NP_036219.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, which results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AJ420443, AK055092
    Consensus CDS
    CCDS6958.1
    UniProtKB/Swiss-Prot
    A6NI44, A6NJB9, Q5T7U2, Q5T7U3, Q8N2U7, Q8N857, Q96GD9, Q9H4P2, Q9Y5Q8
    UniProtKB/TrEMBL
    Q5T7U1
    Related
    ENSP00000361169.5, ENST00000372097.10
    Conserved Domains (1) summary
    pfam09734
    Location:24 → 322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    133030708..133058503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015315.2 → XP_016870804.1  general transcription factor 3C polypeptide 5 isoform X3

    UniProtKB/TrEMBL
    Q5T7U1

  2. XM_017015316.2 → XP_016870805.1  general transcription factor 3C polypeptide 5 isoform X4

    UniProtKB/TrEMBL
    Q5T7U1

  3. XM_047424081.1 → XP_047280037.1  general transcription factor 3C polypeptide 5 isoform X2

  4. XM_047424080.1 → XP_047280036.1  general transcription factor 3C polypeptide 5 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    145244842..145272659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364176.1 → XP_054220151.1  general transcription factor 3C polypeptide 5 isoform X3

  2. XM_054364177.1 → XP_054220152.1  general transcription factor 3C polypeptide 5 isoform X4

  3. XM_054364175.1 → XP_054220150.1  general transcription factor 3C polypeptide 5 isoform X2

  4. XM_054364174.1 → XP_054220149.1  general transcription factor 3C polypeptide 5 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5Q8.2 GenPept UniProtKB/Swiss-Prot:Q9Y5Q8

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