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MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1 like [ Homo sapiens (human) ]

Gene ID: 93487, updated on 5-Mar-2024

Summary

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Official Symbol
MAPK1IP1Lprovided by HGNC
Official Full Name
mitogen-activated protein kinase 1 interacting protein 1 likeprovided by HGNC
Primary source
HGNC:HGNC:19840
See related
Ensembl:ENSG00000168175 MIM:617226; AllianceGenome:HGNC:19840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MISS; C14orf32; c14_5346
Expression
Ubiquitous expression in bone marrow (RPKM 15.9), kidney (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
14q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55051647..55070194)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49256836..49275383)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55518365..55536912)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene ribosomal protein SA pseudogene 13 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:55493639-55494166 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:55494167-55494693 Neighboring gene suppressor of cytokine signaling 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:55517727-55518416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8424 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:55543983-55545182 Neighboring gene uncharacterized LOC124903318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8425 Neighboring gene Sharpr-MPRA regulatory region 8345 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:55574032-55575231 Neighboring gene uncharacterized LOC124903319

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate. Lefebvre C, et al. J Cell Biol, 2002 May 13. PMID 12011110, Free PMC Article
  2. The DNA sequence and analysis of human chromosome 14. Heilig R, et al. Nature, 2003 Feb 6. PMID 12508121
  3. SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses. Banerjee AK, et al. Cell, 2020 Nov 25. PMID 33080218, Free PMC Article
  4. Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. Gallardo-Vara E, et al. Cells, 2019 Sep 13. PMID 31540324, Free PMC Article
  5. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC23138

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
MAPK-interacting and spindle-stabilizing protein-like
Names
MAPK-interacting and spindle-stabilizing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144578.4 → NP_653179.1  MAPK-interacting and spindle-stabilizing protein-like

    See identical proteins and their annotated locations for NP_653179.1

    Status: VALIDATED

    Source sequence(s)
    AL139316
    Consensus CDS
    CCDS32085.1
    UniProtKB/Swiss-Prot
    B2RDD8, Q8NDC0, Q96BG5
    Related
    ENSP00000378851.3, ENST00000395468.9
    Conserved Domains (1) summary
    pfam15822
    Location:5 → 242
    MISS; MAPK-interacting and spindle-stabilizing protein-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    55051647..55070194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537362.3 → XP_011535664.3  MAPK-interacting and spindle-stabilizing protein-like isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    49256836..49275383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377023.1 → XP_054232998.1  MAPK-interacting and spindle-stabilizing protein-like isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NDC0.4 GenPept UniProtKB/Swiss-Prot:Q8NDC0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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