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GSTO1 glutathione S-transferase omega 1 [ Homo sapiens (human) ]

Gene ID: 9446, updated on 7-Apr-2024

Summary

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Official Symbol
GSTO1provided by HGNC
Official Full Name
glutathione S-transferase omega 1provided by HGNC
Primary source
HGNC:HGNC:13312
See related
Ensembl:ENSG00000148834 MIM:605482; AllianceGenome:HGNC:13312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21
Summary
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in liver (RPKM 91.8), heart (RPKM 47.6) and 25 other tissues See more
Orthologs
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Genomic context

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See GSTO1 in Genome Data Viewer
Location:
10q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (104254173..104267455)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (105142310..105155591)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (106013931..106027213)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 43 Neighboring gene tropomyosin 3 pseudogene Neighboring gene Sharpr-MPRA regulatory region 1977 Neighboring gene microRNA 609 Neighboring gene Sharpr-MPRA regulatory region 2425 Neighboring gene uncharacterized LOC124902497 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106013818-106014332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3983 Neighboring gene microRNA 4482 Neighboring gene glutathione S-transferase omega 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:106058991-106060190 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:106060509-106061008

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1. Oakley AJ. Biochem Biophys Res Commun, 2022 Jan 29. PMID 34959192
  2. Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor. Xu Y, et al. Cancer Res, 2020 Sep 1. PMID 32571799, Free PMC Article
  3. GSTO1 regards as a meritorious regulator in cutaneous malignant melanoma cells. Wang LK, et al. Mol Cell Probes, 2019 Dec. PMID 31525447
  4. Glutathione transferase Omega 1-1 (GSTO1-1) modulates Akt and MEK1/2 signaling in human neuroblastoma cell SH-SY5Y. Saisawang C, et al. Proteins, 2019 Jul. PMID 30874320
  5. Skin score correlates with global DNA methylation and GSTO1 A140D polymorphism in arsenic-affected population of Eastern India. Majumder M, et al. Toxicol Mech Methods, 2017 Jul. PMID 28436716

See all (146) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GSTO1 confers drug resistance in HCT116 colon cancer cells through an interaction with TNFalphaIP3/A20.
    Title: GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20.
  2. The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
    Title: The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
  3. Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1.
    Title: Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1.
  4. Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
    Title: Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
  5. Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
    Title: Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
  6. Gene Expression of Antioxidant Enzymes in the Resected Intestine in Crohn's Disease.
    Title: Gene Expression of Antioxidant Enzymes in the Resected Intestine in Crohn's Disease.
  7. Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
    Title: Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
  8. Glutathione Stransferase omega 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of nonsmall cell lung cancer cells, via the JAK/STAT3 signaling pathway.
    Title: Glutathione S‑transferase ω 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of non‑small cell lung cancer cells, via the JAK/STAT3 signaling pathway.
  9. Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor.
    Title: Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor.
  10. Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
    Title: Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686H13163

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione dehydrogenase (ascorbate) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione dehydrogenase (ascorbate) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylarsonate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-ascorbic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-ascorbic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
glutathione S-transferase omega-1
Names
MMA(V) reductase
S-(Phenacyl)glutathione reductase
epididymis secretory protein Li 21
glutathione S-transferase omega 1-1
glutathione-S-transferase like
glutathione-dependent dehydroascorbate reductase
monomethylarsonic acid reductase
NP_001177931.1
NP_001177932.1
NP_004823.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023362.1 RefSeqGene

    Range
    5699..18262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001191002.2 → NP_001177931.1  glutathione S-transferase omega-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    CA431506, CN283947, DT220068
    Consensus CDS
    CCDS53572.1
    UniProtKB/TrEMBL
    Q5TA01
    Related
    ENSP00000358724.4, ENST00000369710.8
    Conserved Domains (3) summary
    cd03184
    Location:84 → 196
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    COG0625
    Location:26 → 177
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03055
    Location:5 → 94
    GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

  2. NM_001191003.2 → NP_001177932.1  glutathione S-transferase omega-1 isoform 3

    See identical proteins and their annotated locations for NP_001177932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL139341, CA431506, CF130513, DB501888
    Consensus CDS
    CCDS53573.1
    UniProtKB/TrEMBL
    Q5TA02
    Related
    ENSP00000441488.1, ENST00000539281.5
    Conserved Domains (3) summary
    PRK10542
    Location:12 → 192
    PRK10542; glutathionine S-transferase; Provisional
    cd03184
    Location:80 → 201
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    cl00388
    Location:1 → 66
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. NM_004832.3 → NP_004823.1  glutathione S-transferase omega-1 isoform 1

    See identical proteins and their annotated locations for NP_004823.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BX537431
    Consensus CDS
    CCDS7555.1
    UniProtKB/Swiss-Prot
    D3DRA3, F5H7H0, P78417, Q5TA03, Q7Z3T2
    UniProtKB/TrEMBL
    B2R983, V9HWG9
    Related
    ENSP00000358727.5, ENST00000369713.10
    Conserved Domains (2) summary
    cd03184
    Location:108 → 229
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    cd03055
    Location:5 → 94
    GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    104254173..104267455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    105142310..105155591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P78417.2 GenPept UniProtKB/Swiss-Prot:P78417

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