U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

caiT L-carnitine:gamma-butyrobetaine antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944765, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
caiT
Gene description
L-carnitine:gamma-butyrobetaine antiporter
Primary source
ASAP:ABE-0000141
Locus tag
b0040
See related
ECOCYC:EG11561
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0041; yaaP
Summary
CaiT does not require an ion gradient and does not respond to osmotic stress. [More information is available at EcoGene: EG11561]. CaiT is a carnitine transporter belonging to the Betaine, Carnitine, Chromium Transport (BCCT) Family . [More information is available at EcoCyc: EG11561].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (40417..41931, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene gamma-butyrobetainyl-CoA:carnitine CoA transferase Neighboring gene crotonobetainyl-CoA reductase Neighboring gene putative electron transfer flavoprotein FixA Neighboring gene putative electron transfer flavoprotein FixB

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A conformational switch in a partially unwound helix selectively determines the pathway for substrate release from the carnitine/γ-butyrobetaine antiporter CaiT. Zomot E, et al. J Biol Chem, 2012 Sep 14. PMID 22843728, Free PMC Article
  2. Oligomeric structure of the carnitine transporter CaiT from Escherichia coli. Vinothkumar KR, et al. J Biol Chem, 2006 Feb 24. PMID 16365043
  3. Role of wet experiment design in data generation: from in vivo to in silico and back. Cánovas M, et al. In Silico Biol, 2007. PMID 17822388
  4. A possible role of ProP, ProU and CaiT in osmoprotection of Escherichia coli by carnitine. Verheul A, et al. J Appl Microbiol, 1998 Dec. PMID 9871325
  5. Regulation of the carnitine pathway in Escherichia coli: investigation of the cai-fix divergent promoter region. Buchet A, et al. J Bacteriol, 1998 May. PMID 9573142, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. conformational switch in a partially unwound helix selectively determines the pathway for substrate release from the carnitine/gamma-butyrobetaine antiporter CaiT
    Title: A conformational switch in a partially unwound helix selectively determines the pathway for substrate release from the carnitine/γ-butyrobetaine antiporter CaiT.
  2. analysis of Escherichia coli CaiT oligomeric structure
    Title: Oligomeric structure of the carnitine transporter CaiT from Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in (R)-carnitine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in (R)-carnitine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in 4-(trimethylammonio)butanoate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carnitine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within carnitine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nitrogen compound transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
L-carnitine:gamma-butyrobetaine antiporter

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    40417..41931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414582.1 L-carnitine:gamma-butyrobetaine antiporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414582.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A478KH75
    Conserved Domains (1) summary
    PRK03356
    Location:1 → 504
    PRK03356; L-carnitine/gamma-butyrobetaine antiport BCCT transporter
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.