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apaH diadenosine tetraphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944770, updated on 4-Feb-2024

Summary

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Gene symbol
apaH
Gene description
diadenosine tetraphosphatase
Primary source
ASAP:ABE-0000167
Locus tag
b0049
See related
ECOCYC:EG10048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cfcB; ECK0050
Summary
Required for invasion of cultured mammalian cells by S. typhimurium. [More information is available at EcoGene: EG10048]. The apaH gene encodes diadenosine tetraphosphatase (diadenosine 5', 5'''-P1, P4-tetraphosphate pyrophosphohydrolase) . [More information is available at EcoCyc: EG10048].
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Genomic context

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Sequence:
NC_000913.3 (50380..51222, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulator of KefC-mediated potassium transport and quinone oxidoreductase Neighboring gene K(+) : H(+) antiporter KefC Neighboring gene dihydrofolate reductase Neighboring gene DUF525 domain-containing protein ApaG Neighboring gene 16S rRNA m(6)2A1518,m(6)2A1519 dimethyltransferase Neighboring gene 4-hydroxythreonine-4-phosphate dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Preparation, crystallization and preliminary X-ray crystallographic studies of diadenosine tetraphosphate hydrolase from Shigella flexneri 2a. Hu W, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Dec 1. PMID 16511239, Free PMC Article
  2. A search for virulence genes of Haemophilus parasuis using differential display RT-PCR. Hill CE, et al. Vet Microbiol, 2003 Oct 17. PMID 14519336
  3. Conservation analysis and structure prediction of the protein serine/threonine phosphatases. Sequence similarity with diadenosine tetraphosphatase from Escherichia coli suggests homology to the protein phosphatases. Barton GJ, et al. Eur J Biochem, 1994 Feb 15. PMID 8119291
  4. Catabolism of diadenosine 5',5"'-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5',5"'-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12. Guranowski A, et al. J Biol Chem, 1983 Dec 25. PMID 6317672
  5. Heat shock and hydrogen peroxide responses of Escherichia coli are not changed by dinucleoside tetraphosphate hydrolase overproduction. Plateau P, et al. J Bacteriol, 1987 Aug. PMID 3038851, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: The gene for Escherichia coli diadenosine tetraphosphatase is located immediately clockwise to folA and forms an operon with ksgA.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity IEA
Inferred from Electronic Annotation
more info
  
enables bis(5'-nucleosyl)-tetraphosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA decapping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA decapping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA decapping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleobase-containing small molecule interconversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
diadenosine tetraphosphatase
NP_414591.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    50380..51222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414591.1 diadenosine tetraphosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414591.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QAX2
    Conserved Domains (1) summary
    TIGR00668
    Location:1 → 279
    apaH; bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
Nucleotide Protein
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