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mraY phospho-N-acetylmuramoyl-pentapeptide-transferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944814, updated on 11-Apr-2024

Summary

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Gene symbol
mraY
Gene description
phospho-N-acetylmuramoyl-pentapeptide-transferase
Primary source
ASAP:ABE-0000316
Locus tag
b0087
See related
ECOCYC:EG10604
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0088; murX
Summary
The aspartic acid residues DD115, D116, and D267 are necessary for catalysis. [More information is available at EcoGene: EG10604].
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Genomic context

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Sequence:
NC_000913.3 (96002..97084)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidoglycan DD-transpeptidase FtsI Neighboring gene ncRNA Neighboring gene UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Neighboring gene D-alanyl-D-alanine-adding enzyme Neighboring gene UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Neighboring gene peptidoglycan glycosyltransferase FtsW Neighboring gene N-acetylglucosaminyl transferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of MraY inhibition by the phiX174 protein E. Zheng Y, et al. Genetics, 2008 Nov. PMID 18791230, Free PMC Article
  2. Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli: catalytic role of conserved aspartic acid residues. Lloyd AJ, et al. J Bacteriol, 2004 Mar. PMID 14996806, Free PMC Article
  3. mraY is an essential gene for cell growth in Escherichia coli. Boyle DS, et al. J Bacteriol, 1998 Dec. PMID 9829961, Free PMC Article
  4. Modes of action of tunicamycin, liposidomycin B, and mureidomycin A: inhibition of phospho-N-acetylmuramyl-pentapeptide translocase from Escherichia coli. Brandish PE, et al. Antimicrob Agents Chemother, 1996 Jul. PMID 8807054, Free PMC Article
  5. The Escherichia coli mraY gene encoding UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase. Ikeda M, et al. J Bacteriol, 1991 Feb. PMID 1846850, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. It is postulated that the involvement of MurG in the peptidoglycan synthesis concurs with two complexes, one implicated in cell elongation and the other in division.
    Title: The essential peptidoglycan glycosyltransferase MurG forms a complex with proteins involved in lateral envelope growth as well as with proteins involved in cell division in Escherichia coli.
  2. results imply that the interaction of bacteriophage phiX174 lysis protein E with MraY is not at the MraY active site, and suggest that a protein-protein interaction is formed between E of PhiX174 and MraY at a site within the transmembrane region
    Title: Interaction of the transmembrane domain of lysis protein E from bacteriophage phiX174 with bacterial translocase MraY and peptidyl-prolyl isomerase SlyD.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospho-N-acetylmuramoyl-pentapeptide-transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospho-N-acetylmuramoyl-pentapeptide-transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospho-N-acetylmuramoyl-pentapeptide-transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall macromolecule biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospho-N-acetylmuramoyl-pentapeptide-transferase
NP_414629.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    96002..97084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414629.1 phospho-N-acetylmuramoyl-pentapeptide-transferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414629.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AED1, A0A775UT54
    Conserved Domains (1) summary
    PRK00108
    Location:16 → 360
    mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional
Nucleotide Protein
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