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lpd lipoamide dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944854, updated on 4-Apr-2024

Summary

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Gene symbol
lpd
Gene description
lipoamide dehydrogenase
Primary source
ASAP:ABE-0000404
Locus tag
b0116
See related
ECOCYC:EG10543
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dhl; ECK0115; lpdA
Summary
Holoenzyme is AceE(24)+AceF(24)+Lpd(12). [More information is available at EcoGene: EG10543]. Lipoamide dehydrogenase is the E3 component of three multicomponent enzyme complexes: |FRAME: [More information is available at EcoCyc: EG10543].
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Genomic context

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Sequence:
NC_000913.3 (127912..129336)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase E1 component Neighboring gene pyruvate dehydrogenase, E2 subunit Neighboring gene DUF3300 domain-containing protein YacH Neighboring gene AcnB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amino acid substitutions at glutamate-354 in dihydrolipoamide dehydrogenase of Escherichia coli lower the sensitivity of pyruvate dehydrogenase to NADH. Sun Z, et al. Microbiology (Reading), 2012 May. PMID 22343352
  2. Dihydrolipoamide dehydrogenase mutation alters the NADH sensitivity of pyruvate dehydrogenase complex of Escherichia coli K-12. Kim Y, et al. J Bacteriol, 2008 Jun. PMID 18375566, Free PMC Article
  3. Effect of lpdA gene knockout on the metabolism in Escherichia coli based on enzyme activities, intracellular metabolite concentrations and metabolic flux analysis by 13C-labeling experiments. Li M, et al. J Biotechnol, 2006 Mar 23. PMID 16310273
  4. alpha-Keto acid dehydrogenation complexes. IV. Resolution and reconstitution of the Escherichia coli pyruvate dehydrogenation complex. KOIKE M, et al. J Biol Chem, 1963 Jan. PMID 14034257
  5. FAD insertion is essential for attaining the assembly competence of the dihydrolipoamide dehydrogenase (E3) monomer from Escherichia coli. Lindsay H, et al. J Biol Chem, 2000 Nov 24. PMID 10970889

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex.
    Title: Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex.
  2. Glutamate at position 354 plays a structural role in establishing the NADH sensitivity of LPD and the PDH complex by lowering the affinity for NADH.
    Title: Amino acid substitutions at glutamate-354 in dihydrolipoamide dehydrogenase of Escherichia coli lower the sensitivity of pyruvate dehydrogenase to NADH.
  3. results show that a mutation in LPD led to a pyruvate dehydrogenase complex that is less sensitive to inhibition by NADH
    Title: Dihydrolipoamide dehydrogenase mutation alters the NADH sensitivity of pyruvate dehydrogenase complex of Escherichia coli K-12.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
lipoamide dehydrogenase
NP_414658.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    127912..129336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414658.1 lipoamide dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414658.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H2YWK3, A0A7U9AQ92, A0AA86XEM4, D6II75
    Conserved Domains (1) summary
    PRK06467
    Location:3 → 472
    PRK06467; dihydrolipoamide dehydrogenase; Reviewed
Nucleotide Protein
Heading Accession and Version

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