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caiC carnitine--CoA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944886, updated on 4-Feb-2024

Summary

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Gene symbol
caiC
Gene description
carnitine--CoA ligase
Primary source
ASAP:ABE-0000133
Locus tag
b0037
See related
ECOCYC:EG11558
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0038; yaaM
Summary
Simliarity comparisons with Salmonella, Desulfotomaculum, Shewanella and Proteus CaiC homologs indicate that the second ATG is the likely start site, which also has a good predicted RBS of GGAG (Personal communication, G. [More information is available at EcoGene: EG11558]. Carnitine-CoA ligase (CaiC) catalyzes the transfer of CoA to carnitine. [More information is available at EcoCyc: EG11558].
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Genomic context

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Sequence:
NC_000913.3 (36271..37824, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transferase CaiE Neighboring gene crotonobetainyl-CoA hydratase Neighboring gene gamma-butyrobetainyl-CoA:carnitine CoA transferase Neighboring gene crotonobetainyl-CoA reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Redirecting metabolic fluxes through cofactor engineering: Role of CoA-esters pool during L(-)-carnitine production by Escherichia coli. Bernal V, et al. J Biotechnol, 2007 Oct 31. PMID 17617487
  2. Role of wet experiment design in data generation: from in vivo to in silico and back. Cánovas M, et al. In Silico Biol, 2007. PMID 17822388
  3. Regulation of the carnitine pathway in Escherichia coli: investigation of the cai-fix divergent promoter region. Buchet A, et al. J Bacteriol, 1998 May. PMID 9573142, Free PMC Article
  4. Identification and characterization of the caiF gene encoding a potential transcriptional activator of carnitine metabolism in Escherichia coli. Eichler K, et al. J Bacteriol, 1996 Mar. PMID 8631699, Free PMC Article
  5. A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Zaslaver A, et al. Nat Methods, 2006 Aug. PMID 16862137

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables CoA-ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables acid-thiol ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carnitine-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables crotonobetaine-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables crotonobetaine-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables crotonobetaine-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carnitine--CoA ligase
NP_414579.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    36271..37824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414579.4 carnitine--CoA ligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414579.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    U9ZXZ3
    Conserved Domains (1) summary
    PRK08008
    Location:1 → 517
    caiC; putative crotonobetaine/carnitine-CoA ligase; Validated
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials