U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ldcC lysine decarboxylase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944887, updated on 6-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
ldcC
Gene description
lysine decarboxylase 2
Primary source
ASAP:ABE-0000633
Locus tag
b0186
See related
ECOCYC:G6094
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0185; ldc; ldcH
Summary
There are two lysine decarboxylases in Escherichia coli, encoded by the cadA and ldcC genes . [More information is available at EcoCyc: G6094].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (209679..211820)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase III subunit alpha Neighboring gene acetyl-CoA carboxyltransferase subunit alpha Neighboring gene VOC domain-containing protein YaeR Neighboring gene tRNA(Ile)-lysidine synthetase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of a Whole-Cell Biotransformation Using a Constitutive Lysine Decarboxylase from Escherichia coli for the High-Level Production of Cadaverine from Industrial Grade L-Lysine. Shin J, et al. Appl Biochem Biotechnol, 2018 Aug. PMID 29374336
  2. Cadaverine biosynthesis contributes to decreased Escherichia coli susceptibility to antibiotics. Akhova A, et al. Res Microbiol, 2021 Nov-Dec. PMID 34543694
  3. Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins. Malet H, et al. Elife, 2014 Aug 5. PMID 25097238, Free PMC Article
  4. RpoS-dependent expression of the second lysine decarboxylase gene in Escherichia coli. Kikuchi Y, et al. Biosci Biotechnol Biochem, 1998 Jun. PMID 9692215
  5. Expression of the second lysine decarboxylase gene of Escherichia coli. Lemonnier M, et al. Microbiology (Reading), 1998 Mar. PMID 9534244

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cadaverine biosynthesis contributes to decreased Escherichia coli susceptibility to antibiotics.
    Title: Cadaverine biosynthesis contributes to decreased Escherichia coli susceptibility to antibiotics.
  2. This study reveals that EcLdcC is a promising whole-cell biocatalyst for the bio-based production of cadaverine from industrial grade L-lysine in comparison to EcCadA.
    Title: Characterization of a Whole-Cell Biotransformation Using a Constitutive Lysine Decarboxylase from Escherichia coli for the High-Level Production of Cadaverine from Industrial Grade L-Lysine.
  3. The structural principles of the LdcI-RavA interaction are being described using molecular modeling.
    Title: Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins.
  4. N-terminus verified by Edman degradation on complete protein
    Title: The Escherichia coli ldcC gene encodes another lysine decarboxylase, probably a constitutive enzyme.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysine decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
lysine decarboxylase 2
NP_414728.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    209679..211820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414728.1 lysine decarboxylase 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414728.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EC57
    Conserved Domains (1) summary
    PRK15399
    Location:1 → 713
    PRK15399; lysine decarboxylase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.