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pdxA 4-hydroxythreonine-4-phosphate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944919, updated on 23-Nov-2023

Summary

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Gene symbol
pdxA
Gene description
4-hydroxythreonine-4-phosphate dehydrogenase
Primary source
ASAP:ABE-0000178
Locus tag
b0052
See related
ECOCYC:EG10691
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0053
Summary
Converts 4-hydroxy-L-threonine phosphate (HTP) to 3-amino-2-oxopropyl phosphate. [More information is available at EcoGene: EG10691]. The crystal structure of PdxA has been solved at 1.96 A resolution. [More information is available at EcoCyc: EG10691].
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Genomic context

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Sequence:
NC_000913.3 (52427..53416, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene diadenosine tetraphosphatase Neighboring gene DUF525 domain-containing protein ApaG Neighboring gene 16S rRNA m(6)2A1518,m(6)2A1519 dimethyltransferase Neighboring gene chaperone SurA Neighboring gene lipopolysaccharide assembly protein LptD Neighboring gene co-chaperone protein DjlA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biosynthesis of vitamin B6: direct identification of the product of the PdxA-catalyzed oxidation of 4-hydroxy-l-threonine-4-phosphate using electrospray ionization mass spectrometry. Banks J, et al. Bioorg Med Chem Lett, 2004 Apr 5. PMID 15026039
  2. Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12. Man TK, et al. J Bacteriol, 1996 Apr. PMID 8636054, Free PMC Article
  3. Genetic organization and restriction enzyme cleavage map of the ksgA-pdxA region of the Escherichia coli chromosome. Andrésson OS, et al. Mol Gen Genet, 1980. PMID 6256606
  4. Recent progress of vitamin B6 biosynthesis. Sakai A, et al. J Nutr Sci Vitaminol (Tokyo), 2004 Apr. PMID 15242009
  5. Growth response to 4-hydroxy-L-threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis. Drewke C, et al. FEBS Lett, 1993 Mar 1. PMID 8440369

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-hydroxythreonine-4-phosphate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-hydroxythreonine-4-phosphate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-hydroxythreonine-4-phosphate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables cobalt ion binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pyridoxal phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyridoxal phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyridoxal phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyridoxine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyridoxine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyridoxine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
4-hydroxythreonine-4-phosphate dehydrogenase
NP_414594.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    52427..53416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414594.1 4-hydroxythreonine-4-phosphate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414594.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7YKC4
    Conserved Domains (1) summary
    PRK00232
    Location:1 → 329
    pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed
Nucleotide Protein
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