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ltaE low-specificity L-threonine aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944955, updated on 4-Apr-2024

Summary

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Gene symbol
ltaE
Gene description
low-specificity L-threonine aldolase
Primary source
ASAP:ABE-0002954
Locus tag
b0870
See related
ECOCYC:G6455
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0861; ltaA; ybjU
Summary
The L-threonine aldolase encoded by the ltaA gene is of the low-specificity type; it can act on both L-threonine and L-allo-threonine as well as L-threo-phenylserine and L-erythro-phenylserine, but does not utilize the D isomers. [More information is available at EcoCyc: G6455].
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Genomic context

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Sequence:
NC_000913.3 (908293..909294, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylmuramoyl-L-alanine amidase D Neighboring gene putative epimerase YbjS Neighboring gene putative NAD(P)-binding protein YbjT Neighboring gene pyruvate oxidase Neighboring gene NADH oxidoreductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. On the catalytic mechanism and stereospecificity of Escherichia coli L-threonine aldolase. di Salvo ML, et al. FEBS J, 2014 Jan. PMID 24165453, Free PMC Article
  2. Diastereoselective synthesis of L: -threo-3,4-dihydroxyphenylserine by low-specific L: -threonine aldolase mutants. Gwon HJ, et al. Biotechnol Lett, 2010 Jan. PMID 19760118
  3. Serine hydroxymethyl transferase from Streptococcus thermophilus and L-threonine aldolase from Escherichia coli as stereocomplementary biocatalysts for the synthesis of beta-hydroxy-alpha,omega-diamino acid derivatives. Gutierrez ML, et al. Chemistry, 2008. PMID 18384024
  4. l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions. Contestabile R, et al. Eur J Biochem, 2001 Dec. PMID 11737206
  5. Gene cloning, biochemical characterization and physiological role of a thermostable low-specificity L-threonine aldolase from Escherichia coli. Liu JQ, et al. Eur J Biochem, 1998 Jul 1. PMID 9692922

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Gene cloning, biochemical characterization and physiological role of a thermostable low-specificity L-threonine aldolase from Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-allo-threonine aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-allo-threonine aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-allo-threonine aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables phenylserine aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables threonine aldolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
low-specificity L-threonine aldolase
NP_415391.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    908293..909294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415391.1 low-specificity L-threonine aldolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415391.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N3AZF1
    Conserved Domains (1) summary
    PRK10534
    Location:1 → 333
    PRK10534; L-threonine aldolase; Provisional
Nucleotide Protein
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